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公开(公告)号：EP3271485A1
公开(公告)日：2018-01-24
申请号：EP16765779.0
申请日：2016-03-17
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： The invention relates generally to methods for diagnosis and treatment of follicular lymphoma or diffuse large B cell lymphoma. Specifically, the invention relates to detecting a lysine (K)-specific methyltransferase 2D (KMT2D) alteration to diagnose or treat follicular lymphoma or diffuse large B cell lymphoma.
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公开(公告)号：EP4322940A1
公开(公告)日：2024-02-21
申请号：EP22788925.0
申请日：2022-04-14
IPC分类号： A61K31/34 , A61K31/343 , C07D307/93 , A61P31/12 , A61P31/14 , C07D401/06
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3.发明授权ANTI-TUMOR ANTIBODY-TUMOR SUPPRESSOR FUSION PROTEIN COMPOSITIONS AND METHODS OF USE FOR THE TREATMENT OF CANCER 有权抗肿瘤抗体 - 肿瘤抑制剂融合蛋白组合物及其用于治疗癌症的方法
公开(公告)号：EP2694112B1
公开(公告)日：2017-11-08
申请号：EP12723769.1
申请日：2012-04-06
发明人： WENDEL, Hans-Guido , ORCCHIO, Elisa
IPC分类号： C07K14/715 , C07K14/705 , C07K16/28 , C12N15/62 , G01N33/574 , A61K39/00
CPC分类号： C07K14/705 , A61K2039/505 , C07K14/715 , C07K16/2887 , C07K2317/73 , C07K2319/00 , C07K2319/30 , G01N33/574
摘要： The present invention is directed to methods and compositions for treating cancer, including, hematologic malignancies, such as B-cell malignancies, with anti-tumor antibody-tumor suppressor fusion proteins in order to selectively restore tumor suppressor gene function to cancer cells in which such tumor suppressor gene function has been lost. The present invention is also directed to methods and compositions for diagnosing cancer and for predicting and assessing response to treatment.
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4.发明公开METHODS FOR IDENTIFYING ANTI-CANCER COMPOUNDS 审中-公开VERFAHREN ZUR IDENTIFIZIERUNG VON ANTIKREBSVERBINDUNGEN
公开(公告)号：EP3077542A2
公开(公告)日：2016-10-12
申请号：EP14866844.5
申请日：2014-12-05
发明人： WENDEL, Hans-Guido , WOLFE, Andrew , SINGH, Kamini , ZHONG, Yi , DREWE, Phillip
CPC分类号： G01N33/5011 , A61K31/343 , A61K31/357 , A61K31/429 , A61K31/58 , G01N33/57496 , G01N33/582 , G01N2333/4703 , G01N2333/914 , G01N2500/02 , G01N2500/10 , G01N2800/52
摘要： Methods are provided for identifying agents capable of modulating cap-dependent RNA translation by comparing translation efficiency in the presence and absence of the agent in an in-vitro or in-vivo translation system that comprises eIF4A and an mRNA having one or more eIF4A-dependent translation-controlling motifs. The modulation of translation in the presence of the agent indicates the agent as capable of modulating cap-dependent mRNA translation. The method can be used to identify anti-cancer agents and oncogenes that may be responsible for tumorigenesis.
摘要翻译： 提供了通过比较包含eIF4A和具有一个或多个eIF4A依赖性的mRNA的体外或体内翻译系统中存在和不存在试剂的翻译效率来鉴定能够调节帽依赖性RNA翻译的方法的方法 翻译控制图案。 在试剂存在下调节翻译表明该试剂能够调节帽依赖性mRNA翻译。 该方法可用于鉴定可能导致肿瘤发生的抗癌剂和致癌基因。
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5.发明公开ANTI-TUMOR ANTIBODY-TUMOR SUPPRESSOR FUSION PROTEIN COMPOSITIONS AND METHODS OF USE FOR THE TREATMENT OF CANCER 有权抗肿瘤和体瘤抑制剂融合蛋白的组合物及其用途为癌症的治疗方法
公开(公告)号：EP2694112A2
公开(公告)日：2014-02-12
申请号：EP12723769.1
申请日：2012-04-06
发明人： WENDEL, Hans-Guido , ORCCHIO, Elisa
IPC分类号： A61K47/48 , C12N15/62 , G01N33/574
CPC分类号： C07K14/705 , A61K2039/505 , C07K14/715 , C07K16/2887 , C07K2317/73 , C07K2319/00 , C07K2319/30 , G01N33/574
摘要： The present invention is directed to methods and compositions for treating cancer, including, hematologic malignancies, such as B-cell malignancies, with anti-tumor antibody-tumor suppressor fusion proteins in order to selectively restore tumor suppressor gene function to cancer cells in which such tumor suppressor gene function has been lost. The present invention is also directed to methods and compositions for diagnosing cancer and for predicting and assessing response to treatment.
摘要翻译： 本发明涉及用于以选择性地恢复肿瘤抑制基因的功能，以癌细胞中哪个搜索治疗癌症，包括血液恶性肿瘤，：如B细胞恶性肿瘤，具有抗肿瘤抗体的肿瘤抑制的融合蛋白的方法和组合物 抑癌基因的功能已经丧失。 因此，本发明涉及方法和组合物用于诊断癌症和用于预测和assesing对治疗的反应。
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