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公开(公告)号：EP4015534A1
公开(公告)日：2022-06-22
申请号：EP21201788.3
申请日：2015-12-04
发明人： BRENTJENS, Renier J. , SMITH, Eric L. , LIU, Cheng , LIU, Hong
IPC分类号： C07K16/28 , C07K14/725 , C12N5/10 , A61P35/00 , A61P43/00
摘要： The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor ( e.g ., a G-protein coupled receptor family C group 5 member D (GPRC5D)), and immunoresponsive cells comprising such CARs. The presently disclosed CARs targeting a G-protein coupled receptor ( e.g ., GPRC5D) have enhanced immune-activating properties, including anti-tumor activity.
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公开(公告)号：EP3313883A1
公开(公告)日：2018-05-02
申请号：EP16736667.3
申请日：2016-06-23
IPC分类号： C07K16/28 , A61K39/395 , A61K35/17 , A61K39/00
CPC分类号： C07K16/2818 , A61K35/17 , A61K38/00 , A61K39/39558 , A61K47/6849 , A61K48/00 , A61K2035/124 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K14/70503 , C07K14/7051 , C07K16/2803 , C07K16/30 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/03 , C12N2740/10043 , A61K2300/00
摘要： The present application provides anti-PD-1 antigen-binding proteins or a fragment thereof, as well as nucleic acids encoding anti-PD-1 antigen-binding proteins or CAR T cells expressing such antigen-binding protein or fragment. Also provided are methods of regulating T cells or treating patients using such constructs or cells.
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3.发明公开CHIMERIC ANTIGEN RECEPTORS TARGETING G-PROTEIN COUPLED RECEPTOR AND USES THEREOF 审中-公开靶向G蛋白偶联受体的嵌合型抗原受体及其应用
公开(公告)号：EP3227339A1
公开(公告)日：2017-10-11
申请号：EP15865633.0
申请日：2015-12-04
发明人： BRENTJENS, Renier J. , SMITH, Eric L. , LIU, Cheng
IPC分类号： C07K16/28 , C07K14/725 , C12N5/10
CPC分类号： C07K14/7051 , C07K16/28 , C07K2317/34 , C07K2317/622 , C07K2317/73
摘要： The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor (e.g., a G-protein coupled receptor family C group 5 member D (GPRC5D)), and immunoresponsive cells comprising such CARs. The presently disclosed CARs targeting a G-protein coupled receptor (e.g., GPRC5D) have enhanced immune-activating properties, including anti-tumor activity.
摘要翻译： 本发明公开的主题提供了用于治疗多发性骨髓瘤的方法和组合物。 本发明涉及特异性靶向G蛋白偶联受体（例如G蛋白偶联受体家族C组5成员D（GPRC5D））的嵌合抗原受体（CAR）和包含这种CAR的免疫应答细胞。 目前公开的靶向G蛋白偶联受体（例如GPRC5D）的CAR具有增强的免疫激活性质，包括抗肿瘤活性。
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公开(公告)号：EP4396215A1
公开(公告)日：2024-07-10
申请号：EP22865598.1
申请日：2022-09-02
申请人： Memorial Sloan Kettering Cancer Center , Sloan-Kettering Institute for Cancer Research , Memorial Hospital for Cancer and Allied Diseases , Tri-institutional Therapeutics Discovery Institute, Inc.
IPC分类号： C07K14/705 , C07K16/28 , C12N15/63
CPC分类号： C07K16/2803 , C07K2317/62220130101 , C07K2319/0320130101 , C07K2319/3320130101 , C07K2317/9220130101 , C07K2317/7320130101 , C12N2740/1004120130101 , A61K39/4631 , A61K39/4632 , A61K39/464411 , A61K2239/1020230501 , A61K2239/4820230501 , A61K2239/3120230501 , A61K2239/3820230501 , A61P35/02 , C07K14/7051 , A61K39/4611
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公开(公告)号：EP4396235A2
公开(公告)日：2024-07-10
申请号：EP22865602.1
申请日：2022-09-02
申请人： Memorial Sloan Kettering Cancer Center , Sloan-Kettering Institute for Cancer Research , Memorial Hospital for Cancer and Allied Diseases , Tri-institutional Therapeutics Discovery Institute, Inc.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
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