公开(公告)号：EP1158982A2

公开(公告)日：2001-12-05

申请号：EP00912071.8

申请日：2000-03-01

申请人： Merck & Co., Inc.

发明人： HARTMAN, George, D. ,  LUMMA, William, C., Jr. ,  SISKO, John, T. ,  SMITH, Anthony, M. ,  TUCKER, Thomas, J. ,  BERGMAN, Jeffrey, M

IPC分类号： A61K31/495 ,  A61K31/496 ,  A61K31/551 ,  C07D223/08 ,  C07D241/04 ,  C07D295/04 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14

CPC分类号： C07D233/64

摘要： The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.