公开(公告)号：EP0763129A1

公开(公告)日：1997-03-19

申请号：EP95917585.0

申请日：1995-04-17

申请人： Merck & Co., Inc.

发明人： COQUE, Juan Jose R. ,  ENGUITA, Francisco J. ,  FUENTE, Juan L. ,  LLARENA, Francisco J. ,  LIRAS, Paloma ,  MARTIN, Juan F.

IPC分类号： C12N15 ,  C12N9 ,  C12P35 ,  C12R1

CPC分类号： C12N9/1018 ,  C12P35/06

摘要： DNA encoding the late enzymes involved in the synthesis of the antibiotic cephamycin have been isolated and purified. The particular enzymes are involved in the late steps of cephamycin biosynthesis. These DNA's have been sequenced and cloned into recombinant expression vectors for their recombinant expression in host cells. The DNA's, vectors containing them and recombinant host cells which express them are useful for the production of antibiotics.