公开(公告)号：EP1556142A2

公开(公告)日：2005-07-27

申请号：EP03779188.6

申请日：2003-10-24

申请人： Merck & Co., Inc.

发明人： COSFORD, Nicholas, David, Peter ,  GOVEK, Steven, Patrick ,  HAMILL, Terence, Gerard ,  KAMENECKA, Theodore ,  ROPPE, Jeffrey, Roger ,  SEIDERS, Thomas, Jonathan

IPC分类号： A61P35/00 ,  A61K31/44 ,  A61K31/425 ,  C07D213/62 ,  C07D277/20 ,  C07D417/00

CPC分类号： C07D417/14 ,  A61K51/04 ,  A61K51/0453 ,  A61K51/0455 ,  C07B2200/05 ,  C07D213/22 ,  C07D213/65 ,  C07D277/30 ,  C07D417/06

摘要： The present invention is directed to isotopically labeled alkyne derivative compounds, particularly 11C, 13C, 14C, 18F, 15O, 13N, 35S, 2H, and 3H labeled compounds. In particular, the present invention is directed to 11C, 13C, 14C, 18F, 15O, 13N, 35S, 2H, and 3H labeled heterocyclic alkynes and methods of their preparation. The present invention further includes a method of use of the 11C, 18F, 15O, or 13N labeled heterocyclic alkyne compounds as tracers in positron emission tomography (PET) imaging, particularly in the study of metabolic conditions in mammals, specifically conditions modulated by metabotropic glutamate receptors subtype 5 (mGluR5).