公开(公告)号：EP1474426A2

公开(公告)日：2004-11-10

申请号：EP02775896.0

申请日：2002-09-20

申请人： Merck & Co., Inc.

发明人： CVETOVICH, Raymond ,  WENSLOW, Robert ,  WILLIAMS, John, M. ,  SIDLER, Daniel ,  CROCKER, Louis ,  TUNG, Hsien-Hsin ,  JOHNSON, Brian, K. ,  KUKURA, Joseph, II ,  DOLLING, Ulf

IPC分类号： C07D477/20

CPC分类号： C07D477/20 ,  C07D477/02

摘要： The present invention relates to a process for reducing the levels of organic solvents to pharmaceutically acceptable levels in thermally unstable crystalline carbapenem solids represented by formula (I), or a salt thereof, wherein R1 and R2 are the same or different, and are selected from H, alkyl, aryl, and heteroaryl, comprising washing a carbapenem solid containing organic solvent with an organic solvent containing water; and using vacuum and/or inert gas (hydrated or dry) at low temperature to produce a compound of formula (I) containing pharmaceutically acceptable levels of organic solvents, wherein the water content of the crystalline carbapenem solid, correcting for organic solvents, is maintained at about 13% to about 25% during the process.