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1.发明授权BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权苄基醚和苄氨基β-分泌酶抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP1673078B1
公开(公告)日：2008-05-28
申请号：EP04789263.3
申请日：2004-09-29
申请人： Merck & Co., Inc.
IPC分类号： C07D213/81 , C07D213/86 , A61K31/195 , A61P25/28
CPC分类号： C07D213/81 , C07C255/57 , C07C311/08 , C07C2601/02 , C07D207/06 , C07D207/08 , C07D213/76 , C07D295/192 , C07D333/20 , C07D405/04
摘要： The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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2.发明公开BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权苄基醚和苄氨基β-分泌酶抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP1673078A2
公开(公告)日：2006-06-28
申请号：EP04789263.3
申请日：2004-09-29
申请人： Merck & Co., Inc.
IPC分类号： A61K31/195
CPC分类号： C07D213/81 , C07C255/57 , C07C311/08 , C07C2601/02 , C07D207/06 , C07D207/08 , C07D213/76 , C07D295/192 , C07D333/20 , C07D405/04
摘要： The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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3.发明公开PHENYLCARBOXYLATE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER S DISEASE 审中-公开BENZOAT-BETA-SECRETASE-HEMMER ZUR BEHANDLUNG VON MORBUS ALZHEIMER
公开(公告)号：EP1643986A2
公开(公告)日：2006-04-12
申请号：EP04756168.3
申请日：2004-06-25
申请人： Merck & Co., Inc.
IPC分类号： A61K31/18 , A61K31/235 , A61K31/24 , A61K31/40 , A61K31/445 , C07C63/00 , C07C303/00 , C07D207/18 , C07D211/06
CPC分类号： C07D207/08 , C07C233/66 , C07C255/57 , C07C311/08 , C07C2601/02 , C07D207/06 , C07D295/192 , C07D401/04
摘要： The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并且可用于治疗涉及β-分泌酶的疾病如阿尔茨海默氏病的化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及β-分泌酶的疾病中的用途。
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