公开(公告)号：EP1129105A1

公开(公告)日：2001-09-05

申请号：EP99971813.3

申请日：1999-11-05

申请人： Merck & Co., Inc.

发明人： MACNEIL, Douglas, J. ,  WEINBERG, David, H. ,  VAN DER PLOEG, Leonardus, H., T.

IPC分类号： C07H21/04 ,  C12N1/20 ,  C12N15/00 ,  C12P21/06

CPC分类号： C07K14/723

摘要： The present invention relates to rhesus monkey DNA molecules encoding the melanocortin-4 receptor protein, recombinant vectors comprising DNA molecules encoding rhesus MC-4R, recombinant host cells which contain a recombinant vector encoding rhesus MC-4R, the rhesus MC-4R protein encoded by the DNA molecule, and methods of identifying selective agonists and antagonists of rhesus MC-4R.

公开(公告)号：EP0809648A1

公开(公告)日：1997-12-03

申请号：EP96904553.0

申请日：1996-01-30

申请人： MERCK & CO., INC.

发明人： CASCIERI, Margaret, A. ,  LINEMEYER, David, L. ,  MacNEIL, Douglas, J. ,  SHIAO, Lin-Lin ,  STRADER, Catherine, ,  WEINBERG, David, H. ,  TAN, Carina, P.

IPC分类号： G01N33 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12N15 ,  C12P21 ,  A61K38 ,  C12R1

CPC分类号： C07K14/70571 ,  A61K38/00 ,  C12N2799/026 ,  G01N33/74

摘要： A novel mammalian neuropeptide Y receptor and method of making the receptor are provided. The invention includes DNA encoding the receptor, assays employing the receptor, cells expressing the receptor, antibodies which bind specifically to the receptor, RNA encoded by the DNA sequence or its complementary sequence, and single-stranded DNA with a sequence complementary to the RNA which encodes the receptor. The receptor and assays employing the receptor are useful for identifying compounds which bind to the receptor, including specific modulators of the receptor. Such compounds are useful for treating a variety of disease conditions, including obesity, diabetes, anxiety, hypertension, cocaine withdrawal, congestive heart failure, memory enhancement, cardiac and cerebral vasospasm, pheochromocytoma and ganglioneuroblastoma, and Huntington's, Alzheimer's and Parkinson's diseases.