公开(公告)号：EP1907381A1

公开(公告)日：2008-04-09

申请号：EP06786261.5

申请日：2006-06-30

申请人： Merck & Co., Inc.

发明人： DROPINSKI, James, F. ,  MEINKE, Peter, T. ,  SHI, Guo, Q. ,  ZHANG, Yong

IPC分类号： C07D413/00 ,  C07D307/44 ,  C07D417/00 ,  C07D401/00 ,  A61K31/44 ,  A61K31/42 ,  A61K31/415

CPC分类号： C07D263/44 ,  C07D413/12 ,  C07D417/12

摘要： Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

摘要翻译： 苯氧基苯基和苯氧基苄基恶唑烷-2,4-二酮和噻唑烷-2,4-二酮是PPARγ的激动剂或部分激动剂，并且可用于治疗和控制II型糖尿病症状的高血糖以及血脂异常，高脂血症 ，高胆固醇血症，高甘油三酯血症和通常与2型糖尿病有关的肥胖症。

公开(公告)号：EP1861382A1

公开(公告)日：2007-12-05

申请号：EP06736976.9

申请日：2006-03-03

申请人： Merck & Co., Inc.

发明人： WOOD, Harold, B. ,  MEINKE, Peter, T. ,  SHI, Guo, Q. ,  ZHANG, Yong

IPC分类号： C07D261/20 ,  C07D307/80 ,  C07D413/04 ,  C07D403/04 ,  C07D239/34 ,  A61K31/416 ,  A61K31/423 ,  A61K31/4439 ,  A61K31/513 ,  A61P3/10

CPC分类号： C07D401/04 ,  C07D239/34 ,  C07D261/20 ,  C07D307/80 ,  C07D403/04 ,  C07D413/04

摘要： Fused aromatic compounds of Formula (I) are PPAR gamma agonists or partial agonists and are useful in the treatment or control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

公开(公告)号：EP1709014A1

公开(公告)日：2006-10-11

申请号：EP05722436.2

申请日：2005-01-18

申请人： Merck & Co., Inc.

发明人： SHI, Guo, Q. ,  MEINKE, Peter, T. ,  DROPINSKI, James, F. ,  ZHANG, Yong

IPC分类号： C07D263/44 ,  C07D277/34 ,  A61K31/421 ,  A61K31/426 ,  A61P3/10

CPC分类号： C07D263/44 ,  A61K38/26 ,  A61K38/28 ,  C07D263/64 ,  C07D277/34 ,  A61K2300/00

摘要： Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones of formula (I) are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

公开(公告)号：EP1539136B1

公开(公告)日：2008-07-09

申请号：EP03771907.7

申请日：2003-07-25

申请人： Merck & Co., Inc.

发明人： SHI, Guo, Q. ,  ZHANG, Yong

IPC分类号： C07D307/85 ,  A61K31/352 ,  A61K31/34 ,  A61P3/06

CPC分类号： C07D413/06 ,  A61K31/00 ,  A61K45/06 ,  C07D307/85 ,  C07D307/93 ,  A61K2300/00

摘要： A class of benzodihydrofuran compounds having the structure of formula (I) below and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of conditions and sequelae that are associated with these diseases, such as atherosclerosis.

公开(公告)号：EP1796665A2

公开(公告)日：2007-06-20

申请号：EP05796128.6

申请日：2005-09-12

申请人： Merck & Co., Inc.

发明人： DROPINSKI, James, F. ,  SHI, Guo, Q. ,  ZHANG, Yong

IPC分类号： A61K31/42 ,  C07D261/20

CPC分类号： C07D261/20 ,  C07D413/12

摘要： A class of compounds having Formula (I) and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of developing conditions and sequelae that are associated with these diseases, such as atherosclerosis.

公开(公告)号：EP1709014B1

公开(公告)日：2007-05-30

申请号：EP05722436.2

申请日：2005-01-18

申请人： Merck & Co., Inc.

发明人： SHI, Guo, Q. ,  MEINKE, Peter, T. ,  DROPINSKI, James, F. ,  ZHANG, Yong

IPC分类号： C07D263/44 ,  C07D277/34 ,  A61K31/421 ,  A61K31/426 ,  A61P3/10

CPC分类号： C07D263/44 ,  A61K38/26 ,  A61K38/28 ,  C07D263/64 ,  C07D277/34 ,  A61K2300/00

摘要： Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones of formula (I) are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

公开(公告)号：EP1539136A2

公开(公告)日：2005-06-15

申请号：EP03771907.7

申请日：2003-07-25

申请人： Merck & Co., Inc.

发明人： SHI, Guo, Q. ,  ZHANG, Yong

IPC分类号： A61K31/352 ,  A61K31/34

CPC分类号： C07D413/06 ,  A61K31/00 ,  A61K45/06 ,  C07D307/85 ,  C07D307/93 ,  A61K2300/00

摘要： A class of benzodihydrofuran compounds having the structure of formula (I) below and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of conditions and sequelae that are associated with these diseases, such as atherosclerosis.

摘要翻译： 具有以下式（I）结构的一类苯并二氢呋喃化合物及其药学上可接受的盐可用作治疗化合物，特别是用于治疗高脂血症，高胆固醇血症，血脂异常和其他脂质紊乱，并且用于延迟或减少 与这些疾病相关的疾病和后遗症的风险，例如动脉粥样硬化。