专利检索 ap:("Merck & Co., Inc. (a New Jersey corp.)") AND inv:"REIDER, Paul" 第 1 页

1.

发明公开
SULFATE SALT OF AN HIV PROTEASE INHIBITOR HAVING AN IMPROVED ORAL ABSORPTION AND BIOAVAILABILITY 失效
标题翻译： HIV蛋白酶抑制剂与改进的口服吸收及其生物有效性硫酸盐

公开(公告)号：EP0986554A1

公开(公告)日：2000-03-22

申请号：EP98923741.7

申请日：1998-05-26

申请人： Merck & Co., Inc. (a New Jersey corp.)

发明人： ASKIN, David , HOERRNER, R., Scott , PURICK, Robert, M. , REIDER, Paul , VARSOLONA, Richard, J. , VOLANTE, Ralph, P.

IPC分类号： C07D405/06 , A61K31/495 , A61K31/34

CPC分类号： C07D405/06

摘要： This invention relates to a sulfate salt of an HIV protease inhibitor, Compound (A), which is useful in the treatment of AIDS, ARC or HIV infection in adults and children. More specifically, the invention provides a sulfate salt of the HIV protease inhibitor, Compound (A) having substantially improved solibility in dilute HC1 (gastric acid) solution which results in much greater oral absorption and bioavailability in animal models. Processes for making the sulfate salt of the particular HIV protease inhibitor compounds are also disclosed.