专利检索 ap:("Merck & Co., Inc. (a New Jersey corp.)" OR "ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.") AND inv:"KIM, Peter, S." 第 1 页

1.

发明公开
INHIBITORS OF CORONAVIRUS 审中-公开
标题翻译：缝边的冠状病毒

公开(公告)号：EP1615610A2

公开(公告)日：2006-01-18

申请号：EP04750008.7

申请日：2004-04-12

申请人： Merck & Co., Inc. (a New Jersey corp.) , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.

发明人： KIM, Peter, S. , ECKERT, Debra , GARSKY, Victor, M. , FREIDINGER, Roger, M. , GELEZIUNAS, Romas , PESSI, Antonello

IPC分类号： A61K6/00

CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16043 , C12N2770/20022 , C12N2810/609

摘要： The present invention relates to inhibitors of coronaviruses including severe acute respiratory syndrome (SARS); methods of identifying inhibitors of coronaviruses; methods and compositions useful for therapy (treatment, or prevention) of coronavirus infections. The coronavirus inhibitors target different regions of the coronavirus Spike protein to inhibit coronavirus replication. In particular embodiments, the inhibitors include Five-Helix proteins, HR2 peptides, HR1 peptides, HR1 chimeric peptides. The present invention also features retro-inverso analogue of the coronavirus inhibitors, coronavirus inhibitors containing one or more tryptophan analogs, and / or one or more lactam bridges.