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公开(公告)号：EP1135406A1
公开(公告)日：2001-09-26
申请号：EP99973035.1
申请日：1999-11-30
发明人： GRIMM, Erich, L. , RENAUD, Johanne , ASPIOTIS, Renee , BAYLY, Christopher, I. , ZAMBONI, Robert , BLACK, Shawn
CPC分类号： C07K5/0202 , A61K38/00
摘要： The invention encompasses the novel class of compounds represented by formula I, which are caspase-3 inhibitors. The invention also encompasses certain pharmaceutical compositions for treatment of caspase-3 mediated diseases comprising compounds of formula I.
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2.发明公开4-OXO-1-(3-SUBSTITUTED PHENYL-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXAMIDE PHOSPHODIESTERASE-4 INHIBITORS 有权4-氧代-1-（3-取代的苯基）-1,4-二氢-1,8-二氮杂萘-3-羧酸酰胺ALSPHOSHODIESTERASE-4抑制剂
公开(公告)号：EP1565464A1
公开(公告)日：2005-08-24
申请号：EP03775029.6
申请日：2003-11-19
发明人： DUBE, Daniel , GALLANT, Michel , LACOMBE, Patrick , ASPIOTIS, Renee , DUBE, Laurence , GIRARD, Yves , MACDONALD, Dwight
IPC分类号： C07D471/04 , A61K31/4375 , A61P25/00 , C07D221/00
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I):or a pharmaceutically acceptable salt thereof, are phosphodiesterase 4 inhibitors useful in the treatment of asthma and inflammation and useful for the enhancement of cognition.
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公开(公告)号：EP1317414A2
公开(公告)日：2003-06-11
申请号：EP01973867.3
申请日：2001-09-06
IPC分类号： C07C237/22 , A61K31/16 , A61P31/18 , C07D413/12 , C07D241/44 , C07D239/34 , C07D307/86
CPC分类号： C07D215/233 , C07C237/22 , C07D213/63 , C07D217/24 , C07D239/34 , C07D241/44 , C07D271/06 , C07D307/86 , C07D413/12 , C07D495/04
摘要： This invention encompasses the novel compounds of Formula (I), which are useful in the treatment of caspase-3 mediated diseases. The invention also encompasses certain pharmaceutical compositions comprising compounds of Formula (I) as well as methods for treatment of caspase-3 mediated diseases.
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公开(公告)号：EP1163214A1
公开(公告)日：2001-12-19
申请号：EP00910448.0
申请日：2000-03-13
发明人： HAN, Yongxin , GRIMM, Erich , ASPIOTIS, Renee , FRANCOEUR, Sebastien , ZAMBONI, Robert , PRASIT, Petpiboon , BLACK, Cameron , GIROUX, Andre , BAYLY, Christopher , MCKAY, Daniel
IPC分类号： C07C323/59 , C07D239/34 , C07D271/06 , A61K31/198 , A61P25/00
CPC分类号： C07D239/34 , C07C323/59
摘要： Compounds represented by formula (I):as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, which is implicated in modulating apoptosis.
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