公开(公告)号：EP1761559A2

公开(公告)日：2007-03-14

申请号：EP05766761.0

申请日：2005-06-28

申请人： Merck Patent GmbH

发明人： GILLIES, Stephen, D. ,  WATKINS, Nigel, John ,  BAKER, Matthew, Paul ,  LO, Kin-Ming

IPC分类号： C07K14/565

CPC分类号： C07K16/46 ,  A61K38/00 ,  A61K47/48423 ,  A61K47/6813 ,  C07K14/565 ,  C07K2319/30

摘要： Disclosed are Fc-interferon-beta (Fc-IFN-β) fusion proteins and nucleic acid molecules encoding them. The Fc- IFN-β fusion proteins include variants of the interferon-beta (IFN-β) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.

公开(公告)号：EP1761559B1

公开(公告)日：2009-09-23

申请号：EP05766761.0

申请日：2005-06-28

申请人： Merck Patent GmbH

发明人： GILLIES, Stephen, D. ,  WATKINS, Nigel, John ,  BAKER, Matthew, Paul ,  LO, Kin-Ming

IPC分类号： C07K14/565

CPC分类号： C07K16/46 ,  A61K38/00 ,  A61K47/48423 ,  A61K47/6813 ,  C07K14/565 ,  C07K2319/30

摘要： Disclosed are Fc-interferon-beta (Fc-IFN-β) fusion proteins and nucleic acid molecules encoding them. The Fc- IFN-β fusion proteins include variants of the interferon-beta (IFN-β) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.