公开(公告)号：EP1753721A1

公开(公告)日：2007-02-21

申请号：EP05742232.1

申请日：2005-05-19

申请人： Merck Patent GmbH

发明人： GUEDAT, Philippe ,  COLLONGES, Francois ,  CHEVREUIL, Olivier ,  DUMAS, Hervé ,  DENAULT, Marie Noelle ,  YVON, Stéphane ,  KANE, Peter ,  LAINTON, Julia ,  ROBERTSON, Avril ,  WENDT, Bernd

IPC分类号： C07D211/46 ,  C07D401/12 ,  C07D413/12 ,  C07D405/12 ,  C07D409/12 ,  C07D405/06 ,  C07D401/06 ,  C07D211/96 ,  C07D413/06 ,  A61K31/435 ,  A61P3/00

CPC分类号： C07D211/46 ,  C07D211/96 ,  C07D213/12 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12

摘要： The present invention relates to derivatives of aroyl-O-piperidine structure of the general formula (I): in which R1, R2, R3 and R4 are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper-triglyceridaemia, hypercholesterolaemia and dyslipidaemia, and to the prevention or treatment of obesity.