公开(公告)号：EP1408964A2

公开(公告)日：2004-04-21

申请号：EP02790172.7

申请日：2002-07-10

申请人： MERCK PATENT GmbH

发明人： BARTOSZYK, Gerd ,  RUSS, Hermann ,  SEYFRIED, Christoph ,  WEBER, Frank

IPC分类号： A61K31/4433 ,  A61K31/198 ,  A61K31/15 ,  A61P25/16 ,  A61P25/00

CPC分类号： A61K31/4433

摘要： (R/S)-(-/+)-2-'5-(4-fluorophenyl)-3-pyridylmethylaminomethyl!-chromane or a physiologically acceptable salt thereof and/or (S)-(+)-2-'5-(4-fluorophenyl)-3-pyridylmethylaminomethyl!-chromane or a physiologically acceptable salt thereof are used for the manufacture of a medicament for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders.

公开(公告)号：EP1505974A2

公开(公告)日：2005-02-16

申请号：EP03752716.5

申请日：2003-04-28

申请人： MERCK PATENT GmbH

发明人： WEBER, Frank ,  JACOB, Jutta ,  BARBER, Andrew ,  GOTTSCHLICH, Rudolf

IPC分类号： A61K31/445 ,  A61K31/40 ,  A61K31/485 ,  A61K31/135 ,  A61P3/04

CPC分类号： A61K31/40 ,  A61K31/135 ,  A61K31/445 ,  A61K31/485

摘要： The instant invention relates to the use of compounds that are effective as selective opiate receptor modulators for the manufacture of pharmaceuticals for the diagnosis and/or the treatment of disorders, said disorders being selected from eating disorders and digestive disorders, especially psychogenic eating disorders, for the manufacture of a pharmaceutical effective for modulating the gastrointestinal tonus, and to pharmaceutical composition, comprising one or more of said modulator compounds and one or more compounds that are effective as appetite depressant.

公开(公告)号：EP1397128A1

公开(公告)日：2004-03-17

申请号：EP02724228.8

申请日：2002-03-13

申请人： MERCK PATENT GmbH

发明人： JACOB, Jutta ,  WEBER, Frank ,  BARTOSZYK, Gerd ,  SEYFRIED, Christoph

IPC分类号： A61K31/40 ,  A61P13/10

CPC分类号： A61K31/40

摘要： The invention relates to the use of a medicament n-methyl-N-[(1S)-1-phenyl-2((3S)-3-hydroxypyrrolidin-1-yl)-ethyl]-2,2-diphenyl-acetamide or one of the pharmacologically acceptable salts thereof for the production of medicament formulations for the treatment of bladder diseases, particularly irritable bladder syndrome and the pains associated therewith.

公开(公告)号：EP1299099A2

公开(公告)日：2003-04-09

申请号：EP01902375.3

申请日：2001-02-01

申请人： MERCK PATENT GmbH

发明人： BARTOSZYK, Gerd ,  RUSS, Hermann ,  SEYFRIED, Christoph ,  WEBER, Frank

IPC分类号： A61K31/353 ,  A61P25/14 ,  A61P25/16

CPC分类号： A61K31/353 ,  A61K31/4433 ,  A61K45/06 ,  A61K2300/00

摘要： (R)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane or a physiologically acceptable salt thereof is used for the manufacture of a medicament for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders. A preferred salt is (R)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane hydrochloride.

公开(公告)号：EP0790840A1

公开(公告)日：1997-08-27

申请号：EP95936579.0

申请日：1995-11-02

申请人： MERCK PATENT GmbH

发明人： ZORN, Franz ,  WEBER, Frank ,  ALMEIDA, Antonio ,  TAUBERT, Ilona ,  WAGENKNECHT, Rolf ,  EBERLE, Wilhelm

IPC分类号： A61L27 ,  C04B35 ,  C04B38 ,  A61F2

CPC分类号： A61L27/3683 ,  A61F2310/00293 ,  A61K35/32 ,  A61L27/12 ,  A61L27/36 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/56 ,  C04B35/447 ,  C04B38/08 ,  C04B2111/00836

摘要： The invention concerns a process for producing spongiosa bone ceramics having a low calcium oxide content. Between the mineralization of the bone material and the sintering of the ceramics, a washing step is performed with demineralized water, whereby the calcium oxide portions are eliminated from the mineralized bone matrix.

公开(公告)号：EP1427724B1

公开(公告)日：2006-05-03

申请号：EP02767363.1

申请日：2002-08-12

申请人： Merck Patent GmbH

发明人： BÖTTCHER, Henning ,  DEVANT, Ralf ,  BARTOSZYK, Gerd ,  RUSS, Hermann ,  WEBER, Frank ,  SEYFRIED, Christoph

IPC分类号： C07D405/12 ,  A61K31/44 ,  A61P25/16

CPC分类号： C07D405/12

摘要： Compounds of formula I in which R has a meaning as indicated in claim 1, or one of their optical isomers or pharmaceutically acce ptable salts, used for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders and/or for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics.

公开(公告)号：EP1427724A1

公开(公告)日：2004-06-16

申请号：EP02767363.1

申请日：2002-08-12

申请人： MERCK PATENT GmbH

发明人： BÖTTCHER, Henning ,  DEVANT, Ralf ,  BARTOSZYK, Gerd ,  RUSS, Hermann ,  WEBER, Frank ,  SEYFRIED, Christoph

IPC分类号： C07D405/12 ,  A61K31/44 ,  A61P25/16

CPC分类号： C07D405/12

摘要： Compounds of formula I in which R has a meaning as indicated in claim 1, or one of their optical isomers or pharmaceutically acce ptable salts, used for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders and/or for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics.

公开(公告)号：EP1408964B1

公开(公告)日：2007-01-24

申请号：EP02790172.7

申请日：2002-07-10

申请人： Merck Patent GmbH

发明人： BARTOSZYK, Gerd ,  RUSS, Hermann ,  SEYFRIED, Christoph ,  WEBER, Frank

IPC分类号： A61K31/4433 ,  A61P25/16 ,  A61P25/00

CPC分类号： A61K31/4433

摘要： (R/S)-(-/+)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane or a physiologically acceptable salt thereof and/or (S)-(+)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane or a physiologically acceptable salt thereof are used for the manufacture of a medicament for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders.

公开(公告)号：EP1299099B1

公开(公告)日：2005-10-26

申请号：EP01902375.3

申请日：2001-02-01

申请人： Merck Patent GmbH

发明人： BARTOSZYK, Gerd ,  RUSS, Hermann ,  SEYFRIED, Christoph ,  WEBER, Frank

IPC分类号： A61K31/353 ,  A61P25/14 ,  A61P25/16

CPC分类号： A61K31/353 ,  A61K31/4433 ,  A61K45/06 ,  A61K2300/00

摘要： (R)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane or a physiologically acceptable salt thereof is used for the manufacture of a medicament for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders. A preferred salt is (R)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane hydrochloride.