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公开(公告)号：EP2931301B1
公开(公告)日：2018-07-25
申请号：EP13864587.4
申请日：2013-12-12
摘要： A process is described for purifying insulin and insulin analogues that comprises high-pressure liquid chromatography with an acidic cation exchange medium performed under low to moderate pressure at an elevated temperature.
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2.发明公开PURIFYING INSULIN USING CATION EXCHANGE AND REVERSE PHASE CHROMATOGRAPHY IN THE PRESENCE OF AN ORGANIC MODIFIER AND ELEVATED TEMPERATURE 审中-公开胰岛素在高温和有机改性剂的存在下的阳离子交换和反相色谱法CLEANING
公开(公告)号：EP3116531A1
公开(公告)日：2017-01-18
申请号：EP15761797.8
申请日：2015-03-11
发明人： ORTIGOSA, Allison, D. , COLEMAN, Michael, P. , GEORGE, Shibu, T. , RAUSCHER, Michael, A. , SLEEVI, Mark, C. , CHOW, Kartoa
摘要： A process is described for purifying insulin and insulin analogs that comprises high-pressure liquid chromatography with an acidic cation exchange medium performed in the presence of a water miscible organic modifier and at an elevated temperature followed by reverse phase chromatography performed in the presence of a water miscible organic modifier and at an elevated temperature.
摘要翻译： 一种方法是在在升高的温度，然后在水的存在下进行反相色谱法在水混溶性有机改性剂的存在下和在执行的酸性阳离子交换介质描述了用于纯化胰岛素和胰岛素类似物也包括高压液相色谱法，用 混溶的有机改性剂和在升高的温度。
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公开(公告)号：EP2931301A1
公开(公告)日：2015-10-21
申请号：EP13864587.4
申请日：2013-12-12
摘要： A process is described for purifying insulin and insulin analogues that comprises high-pressure liquid chromatography with an acidic cation exchange medium performed under low to moderate pressure at an elevated temperature.
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