专利检索 ap:("Merck Sharp & Dohme Corp.") AND inv:"FLANAGAN, William Michael" 第 1 页

1.

发明公开
A METHOD FOR RAPIDLY EVALUATING PERFORMANCE OF SHORT INTERFERING RNA WITH NOVEL CHEMICAL MODIFICATIONS 审中-公开
标题翻译：程序新的化学修饰的短干扰RNA的表演快评

公开(公告)号：EP2513337A1

公开(公告)日：2012-10-24

申请号：EP10842465.6

申请日：2010-12-09

申请人： Merck Sharp & Dohme Corp.

发明人： BUTORA, Gabor , DAVIES, Ian, W. , FLANAGAN, William Michael , FU, Wenlang , KENSKI, Denise, M. , QI, Ning

IPC分类号： C12Q1/68 , C40B30/10

CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/32 , C12N2310/322 , C12N2310/331 , C12N2320/11 , C12N2320/51

摘要： It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.