公开(公告)号：EP2605772A2

公开(公告)日：2013-06-26

申请号：EP11818552.9

申请日：2011-08-08

申请人： Merck Sharp & Dohme Corp.

发明人： LIMANTO, John ,  BEUTNER, Gregory, L. ,  YIN, Jingjun ,  KLAPARS, Artis ,  ASHLEY, Eric, R. ,  STROTMAN, Hallena, R. ,  TRUPPO, Matthew, D. ,  CHUNG, Cheol, K. ,  HUGHES, Gregory ,  LIU, Zhijian ,  GRAU, Brendan ,  JANEY, Jacob

IPC分类号： A61K31/275

CPC分类号： C07D207/12 ,  C07C217/52 ,  C07D207/416 ,  C12P17/10

摘要： The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates.

公开(公告)号：EP2413941A1

公开(公告)日：2012-02-08

申请号：EP10759391.5

申请日：2010-04-01

申请人： Merck Sharp & Dohme Corp. ,  Merck Canada Inc.

发明人： MCKAY, Daniel, J. ,  ARBOUR, Melissa ,  ASPIOTIS, Renee ,  CHEN, Austin ,  DOLMAN, Sarah Jennifer ,  FOURNIER, Pierre-Andre ,  GALLANT, Michel ,  HAN, Yongxin ,  HUGHES, Greg ,  JANEY, Jacob ,  JUTEAU, Helene ,  LACOMBE, Patrick ,  LALIBERTE, Sebastien ,  LAUZON, Sophie ,  MACDONALD, Dwight ,  MACKAY, Bruce ,  MELLON, Christophe ,  MOLINARO, Carmela ,  MORLEY, Krista, L. ,  O'SHEA, Paul ,  RAMTOHUL, Yeeman, K. ,  SIMARD, Daniel ,  TSUI, Chit

IPC分类号： A61K31/535

CPC分类号： C07D211/26 ,  C07D211/22 ,  C07D211/28 ,  C07D211/52 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14

摘要： The present invention relates to biaryl piperidine-based renin inhibitor compounds, and their use in treating cardiovascular events and renal insufficiency.

摘要翻译： 本发明涉及二芳基哌啶基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。