专利检索 ap:("Merck Sharp & Dohme Corp.") AND inv:"LYLE, Terry, A." 第 1 页

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发明授权
HIV INTEGRASE INHIBITORS 有权
标题翻译： HIV整合

公开(公告)号：EP1756114B1

公开(公告)日：2014-11-19

申请号：EP05743968.9

申请日：2005-05-03

申请人： Merck Sharp & Dohme Corp.

发明人： WAI, John, S. , VACCA, Joseph, P. , ZHUANG, Linghang , KIM, Boyoung , LYLE, Terry, A. , WISCOUNT, Catherine, M. , EGBERTSON, Melissa, S. , NEILSON, Lou Anne , EMBREY, Mark , FISHER, Thorsten, E. , STAAS, Donnette, D.

IPC分类号： C07D487/14 , A61K31/5025 , A61K31/4985

CPC分类号： A61K31/5025 , C07D487/14 , Y02A50/414

摘要： Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.