公开(公告)号：EP2185554A1

公开(公告)日：2010-05-19

申请号：EP08795027.5

申请日：2008-08-05

申请人： Merck Sharp & Dohme Corp.

发明人： GRIMM, Jonathan ,  HEIDEBRECHT, Richard, W., Jr. ,  MAMPREIAN, Dawn, M. ,  METHOT, Joey, L. ,  MILLER, Thomas, A. ,  OTTE, Karin, M. ,  PETERSON, Scott ,  SILIPHAIVANH, Phieng ,  WILSON, Kevin, J. ,  WITTER, David, J.

IPC分类号： C07D471/00

CPC分类号： C07F7/0812

摘要： The present invention relates to a novel class of Silicon derivatives. The Silicon compounds can be used to treat cancer. The Silicon compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the Silicon derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the Silicon derivatives in vivo.