-
公开(公告)号：EP2603079B1
公开(公告)日：2018-09-19
申请号：EP11816846.7
申请日：2011-08-05
发明人： DUDKIN, Vadim , FRALEY, Mark, E. , ARRINGTON, Kenneth, L. , LAYTON, Mark, E. , RODZINAK, Kevin, J. , PERO, Joseph, E. , REIF, Alexander, J.
IPC分类号： C07D401/14 , A01N43/50 , A61K31/415 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D235/26 , C07D403/04 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/14 , C07D453/02 , C07D471/04 , C07D513/14
CPC分类号： C07D235/26 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/14 , C07D453/02 , C07D471/04 , C07D513/14
摘要： The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.
-
公开(公告)号：EP2721029A1
公开(公告)日：2014-04-23
申请号：EP12801127.7
申请日：2012-06-14
发明人： FIJI, Hannah, D. , KELLY, Michael, J., III , KERN, Jeffrey, C. , LAYTON, Mark, E. , PERO, Joseph, E. , REIF, Alexander, J. , ROSSI, Michael, A.
IPC分类号： C07D471/04
CPC分类号： C07D513/04 , C07D471/04 , C07D519/00
摘要： The present invention is directed to imidazopyridin-2-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
-
公开(公告)号：EP2721029B1
公开(公告)日：2018-07-18
申请号：EP12801127.7
申请日：2012-06-14
发明人： FIJI, Hannah, D. , KELLY, Michael, J., III , KERN, Jeffrey, C. , LAYTON, Mark, E. , PERO, Joseph, E. , REIF, Alexander, J. , ROSSI, Michael, A.
IPC分类号： C07D471/04 , C07D513/04 , C07D519/00
CPC分类号： C07D513/04 , C07D471/04 , C07D519/00
摘要： The present invention is directed to imidazopyridin-2-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
-
公开(公告)号：EP2603079A1
公开(公告)日：2013-06-19
申请号：EP11816846.7
申请日：2011-08-05
发明人： DUDKIN, Vadim , FRALEY, Mark, E. , ARRINGTON, Kenneth, L. , LAYTON, Mark, E. , RODZINAK, Kevin, J. , PERO, Joseph, E. , REIF, Alexander, J.
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： C07D235/26 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/14 , C07D453/02 , C07D471/04 , C07D513/14
摘要： The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.
摘要翻译： 本发明涉及作为mGluR2受体的正变构调节剂的苯并咪唑酮衍生物，其用于治疗或预防与谷氨酸功能障碍有关的神经和精神疾病以及涉及mGluR2受体的疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗其中代谢型谷氨酸受体参与的疾病如精神分裂症中的用途。
-
公开(公告)号：EP2579717A2
公开(公告)日：2013-04-17
申请号：EP11792940.6
申请日：2011-06-06
发明人： ARRINGTON, Kenneth, L. , DUDKIN, Vadim , LAYTON, Mark, E. , PERO, Joseph, E. , REIF, Alexander, J.
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： C07D471/04 , C07D519/00 , C07F7/10
摘要： The present invention is directed to 5-substituted 1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-one derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.
-
-
-
-
搜索结果
5 条记录 (耗时 0.019 秒)
