公开(公告)号：EP3204363A1

公开(公告)日：2017-08-16

申请号：EP15849713.1

申请日：2015-10-08

申请人： Merck Sharp & Dohme Corp.

发明人： UJJAINWALLA, Fez ,  TAN, John Qiang ,  DANG, Qun ,  SINZ, Christopher J. ,  CRESPO, Alejandro ,  WANG, Ming ,  CHEN, Yili ,  CAI, Jiaqiang ,  WU, Fan ,  DU, Xiaoxing

IPC分类号： C07D239/26

CPC分类号： C07D239/36 ,  C07D239/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

公开(公告)号：EP3204385A1

公开(公告)日：2017-08-16

申请号：EP15848373.5

申请日：2015-10-08

申请人： Merck Sharp & Dohme Corp.

发明人： UJJAINWALLA, Fez ,  TAN, John Qiang ,  DANG, Qun ,  SINZ, Christopher J. ,  WANG, Ming ,  CHEN, Yili ,  CAI, Jiaqiang

IPC分类号： C07D471/20 ,  C07D401/14 ,  C07D471/04

CPC分类号： C07D239/36 ,  A61P7/06 ,  C07D413/06

摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

摘要翻译： 本发明涉及抑制HIF脯氨酰羟化酶的式I化合物，它们用于增强促红细胞生成素的内源产生的用途，以及用于治疗与促红细胞生成素内源性产生减少有关的疾病如贫血等疾病的药物组合物，以及包含这种化合物 和药物载体。

公开(公告)号：EP3204384A1

公开(公告)日：2017-08-16

申请号：EP15848319.8

申请日：2015-10-08

申请人： Merck Sharp & Dohme Corp.

发明人： UJJAINWALLA, Fez ,  TAN, John Qiang ,  DANG, Qun ,  SINZ, Christopher J. ,  WANG, Ming ,  CAI, Jiaqiang ,  DU, Xiaoxing ,  CHEN, Yili

IPC分类号： C07D471/20 ,  C07D401/14 ,  C07D471/04

CPC分类号： C07D213/82 ,  A61P7/08 ,  C07D401/04

摘要： The present invention concerns compounds of formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

摘要翻译： 本发明涉及抑制HIF脯氨酰羟化酶的式I化合物，它们用于增强促红细胞生成素的内源性产生的用途，以及用于治疗与促红细胞生成素的内源性产生减少有关的疾病如贫血等疾病的药物组合物以及包含这种化合物 和药物载体。