公开(公告)号：EP3302480A1

公开(公告)日：2018-04-11

申请号：EP16804195.2

申请日：2016-05-31

申请人： Merck Sharp & Dohme Corp. ,  Merck Sharp & Dohme B.V.

发明人： DE MAN, Adrianus Petrus Antonius ,  KIM, Ronald ,  LIU, Jian ,  KOZLOWSHI, Joseph A. ,  BOGA, Sobhana Babu ,  FISCHMANN, Thierry ,  GUIADEEN, Deodiasingh ,  POLS-DE ROOIJ, Ilse Hendrica Maria ,  LIU, Shilan ,  WU, Hao

IPC分类号： A61K31/50 ,  A61K31/505 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  A61P19/02

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.