专利检索 ap:("Merck Sharp & Dohme Corp." OR "Merck Sharp & Dohme Limited") AND inv:"LIEBERMAN, David" 第 1 页

1.

发明公开
PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS 审中-公开
标题翻译：用于生产手性二肽基肽酶IV抑制剂

公开(公告)号：EP2725905A1

公开(公告)日：2014-05-07

申请号：EP12804259.5

申请日：2012-06-25

申请人： Merck Sharp & Dohme Corp. , Merck Sharp & Dohme Limited

发明人： TAN, Lushi , CHEN, Qinghao , ZACUTO, Michael, J. , DUNN, Robert, F. , MOMENT, Aaron, J. , JANEY, Jacob, M. , LIEBERMAN, David , SHEEN, Faye , BREMEYER, Nadine , SCOTT, Jeremy , KUETHE, Jeffrey, T.

IPC分类号： A01N43/56

CPC分类号： C07D487/04 , A61K31/4162 , A61K31/4439 , A61K31/4985 , A61K31/513 , C07B2200/13 , Y02P20/55

摘要： A process for the preparation of pyrazolopyrolidines of structural formula I: and W is or P, wherein in P is an amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.