公开(公告)号：EP2326181A1

公开(公告)日：2011-06-01

申请号：EP09806945.3

申请日：2009-08-07

申请人： Merck Sharp & Dohme Corp. ,  Scynexis, Inc.

发明人： GREENLEE, Mark, L. ,  WILKENING, Robert ,  APGAR, James ,  SPERBECK, Donald ,  WILDONGER, Kenneth, James ,  MENG, Dongfang ,  PARKER, Dann, L. Jr. ,  PACOFSKY, Gregory, James ,  HEASLEY, Brian, Haid ,  MAMAI, Ahmed ,  NELSON, Kingsley

IPC分类号： A01N43/64 ,  A61K31/21 ,  A61K31/41

CPC分类号： A61K31/343 ,  A01N43/653 ,  A61K31/21 ,  A61K31/41 ,  C07D493/08 ,  C07D519/00

摘要： Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (l,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs,,as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.

摘要翻译： 本文公开了enfumafungin的新衍生物及其药学上可接受的盐，水合物和前药。 还公开了包含此类化合物的组合物，制备此类化合物的方法以及使用此类化合物作为抗真菌剂和/或（1,3）-β-D-葡聚糖合酶抑制剂的方法。 公开的化合物，它们的药学上可接受的盐，水合物和前药以及包含此类化合物，盐，水合物和前药的组合物可用于治疗和/或预防真菌感染和相关疾病和病症。