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    Avermectin derivatives
    2.
    发明公开
    Avermectin derivatives 失效
    阿维菌素衍生物

    公开(公告)号：EP1671980A2

    公开(公告)日：2006-06-21

    申请号：EP06004047.4

    申请日：1990-01-17

    申请人： Merial Limited

    发明人： Fisher, Michael H. ,  Mrozik, Helmut

    IPC分类号： C07H19/01 ,  A61K31/70 ,  A61P33/00

    CPC分类号： C07H19/01 ,  C07H17/08

    摘要： Novel avermectin derivatives are disclosed, wherein the 5-hydroxy group is replaced by an oxime group. The avermectin-5-oximes can further be derivatized at the 4"- or 4'-positions as amino, substituted amino, acylhydrazone, semicarbazone, or substituted semicarbazone analogues. The avermectin-5-oximes are prepared by the oxidation of the 5-hydroxy compounds with manganese dioxide or with pyridinium dichromate to the known 5-oxo analogues, and these are then reacted with a hydroxylamine salt. The new compounds are potent anti-parasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

    摘要翻译： 公开了新的阿维菌素衍生物，其中5-羟基被肟基替代。 阿维菌素-5-肟可以进一步在4“ - 或4'-位被衍生为氨基，取代的氨基，酰腙，缩氨基脲或取代的缩氨基脲类似物，阿维菌素-5-肟通过氧化5- 羟基化合物与二氧化锰或与重铬酸吡啶鎓转化成已知的5-氧代类似物，然后将它们与羟胺盐反应，新化合物是有效的抗寄生虫剂，特别是该化合物是驱虫剂，杀虫剂和杀螨剂。

    Avermectin derivatives
    3.
    发明公开
    Avermectin derivatives 失效
    Avermectinderivate

    公开(公告)号：EP1671980A3

    公开(公告)日：2006-07-05

    申请号：EP06004047.4

    申请日：1990-01-17

    申请人： Merial Limited

    发明人： Fisher, Michael H. ,  Mrozik, Helmut

    IPC分类号： C07H19/01 ,  A61K31/70 ,  A61P33/00

    CPC分类号： C07H19/01 ,  C07H17/08

    摘要： Novel avermectin derivatives of formula (I) are disclosed, wherein the 5-hydroxy group is replaced by an oxime group. The avermectin-5-oximes can further be derivatized at the 4"- or 4'-positions as amino, substituted amino, acylhydrazone, semicarbazone, or substituted semicarbazone analogues. The avermectin-5-oximes are prepared by the oxidation of the 5-hydroxy compounds with manganese dioxide or with pyridinium dichromate to the known 5-oxo analogues, and these are then reacted with a hydroxylamine salt. The new compounds are potent anti-parasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

    摘要翻译： 公开了式（I）的新型除虫菊酯衍生物，其中5-羟基被肟基取代。 阿维菌素-5-肟可以在4“或4”位进一步衍生为氨基，取代的氨基，酰腙，缩氨基脲或取代的缩氨基脲类似物。除虫菊酯-5-肟通过氧化5- 具有二氧化锰或与重铬酸吡啶鎓的羟基化合物与已知的5-氧代类似物反应，然后将其与羟胺盐反应。新化合物是有效的抗寄生虫剂，特别是化合物是驱肠虫，杀虫剂和杀螨剂。