公开(公告)号：EP3221463A1

公开(公告)日：2017-09-27

申请号：EP15860608.7

申请日：2015-11-18

申请人： Metabolon, Inc.

发明人： PERICHON, Regis ,  BELL, Lauren Nicole ,  WULFF, Jacob ,  NGUYEN, Uyen Thao ,  WATKINS, Steven M.

IPC分类号： C12Q1/00 ,  G01N33/50 ,  G01N33/68

CPC分类号： G01N33/92 ,  G01N33/50 ,  G01N33/5023 ,  G01N33/6806 ,  G01N33/82 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/085 ,  G01N2800/56 ,  G01N2800/7052

摘要： Biomarkers of NASH, NAFLD, and fibrosis and methods for diagnosis (or aiding in the diagnosis) of NAFLD, NASH and/or fibrosis are described herein. Additionally, methods of distinguishing between NAFLD and NASH, methods of classifying the stage of fibrosis, methods of determining the severity of liver disease, methods of determining the severity of liver disease or fibrosis, and methods of monitoring progression/regression of NASH, NAFLD, and/or fibrosis are described herein.

摘要翻译： 本文描述了NASH，NAFLD和纤维化的生物标志物和用于诊断（或帮助诊断）NAFLD，NASH和/或纤维化的方法。 此外，还可区分NAFLD和NASH的方法，纤维化分期方法，确定肝脏疾病严重程度的方法，确定肝脏疾病或纤维化严重程度的方法以及监测NASH，NAFLD进展/退化的方法， 和/或纤维化在本文中描述。