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    SMALL MOLECULE BIOCHEMICAL PROFILING OF INDIVIDUAL SUBJECTS FOR DISEASE DIAGNOSIS AND HEALTH ASSESSMENT
    2.
    发明公开
    SMALL MOLECULE BIOCHEMICAL PROFILING OF INDIVIDUAL SUBJECTS FOR DISEASE DIAGNOSIS AND HEALTH ASSESSMENT 审中-公开
    用于疾病诊断和健康评价人的小分子生化PROFILING

    公开(公告)号：EP3129909A1

    公开(公告)日：2017-02-15

    申请号：EP15721065.9

    申请日：2015-04-08

    申请人： Metabolon, Inc.

    发明人： MILBURN, Michael V. ,  RYALS, John A. ,  GUO, Lining ,  ECKHART, Andrea ,  WULFF, Jacob ,  KENNEDY, Adam D. ,  JÖNSSON, Thomas J. ,  MICHALEK, Ryan Douglas ,  WITTMANN, Bryan ,  MITCHELL, Matthew

    IPC分类号： G06F19/28 ,  G01N33/50

    摘要： Methods and systems are described herein for small molecule biochemical profiling of an individual subject for diagnosis of a disease or disorder, facilitating diagnosis of a disease or disorder, and/or identifying an increased risk of developing a disease or disorder in the individual subject. Aberrant levels of small molecules present in a sample from an individual subject are identified and diagnostic information relevant to the individual subject is obtained based on the identified aberrant levels. The obtained diagnostic information includes one or more of an identification of at least one biochemical pathway associated with the identified subset of the small molecules having aberrant levels, an identification at least one disease or disorder associated with the identified subset of the small molecules having aberrant levels, and an identification of at least one recommended follow up test associated with the identified subset of the small molecules having aberrant levels.

    摘要翻译： 方法描述在用于疾病或病症的诊断的个体对象的小分子生物化学分析，促进疾病或病症的诊断和/或确定在显影个体受试者的疾病或病症的风险增加。 从在个体对象存在于样品中的小分子的异常水平被识别和相关的个体对象的诊断信息是基于所识别的异常水平得到。 所获得的诊断信息包括一个或多个与具有异常水平的小分子的识别的子集相关联的至少一个生化途径的标识，来识别与具有异常水平的小分子的识别的子集相关联的至少一种疾病或病症 ，并在与具有异常水平的小分子的所识别的子集相关联的至少一个推荐的后续测试的标识。