公开(公告)号：EP2164977A2

公开(公告)日：2010-03-24

申请号：EP08780229.4

申请日：2008-07-17

申请人： Metabolon Inc.

发明人： HU, Yun, Fu ,  CHIRILA, Costel ,  ALEXANDER, Danny ,  MILBURN, Michael ,  MITCHELL, Matthew, W. ,  GALL, Walter ,  LAWTON, Kay

IPC分类号： C12Q1/00

CPC分类号： G01N33/5308 ,  G01N33/483 ,  G01N33/487 ,  G01N33/5091 ,  G01N33/6893 ,  G01N2800/04 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

摘要： Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.

公开(公告)号：EP2164977B1

公开(公告)日：2013-10-30

申请号：EP08780229.4

申请日：2008-07-17

申请人： Metabolon, Inc.

发明人： HU, Yun, Fu ,  CHIRILA, Costel ,  ALEXANDER, Danny ,  MILBURN, Michael ,  MITCHELL, Matthew, W. ,  GALL, Walter ,  LAWTON, Kay

IPC分类号： C12Q1/00

CPC分类号： G01N33/5308 ,  G01N33/483 ,  G01N33/487 ,  G01N33/5091 ,  G01N33/6893 ,  G01N2800/04 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

摘要： Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.

公开(公告)号：EP2414535A1

公开(公告)日：2012-02-08

申请号：EP10759343.6

申请日：2010-03-31

申请人： Metabolon Inc.

发明人： HU, Yun, Fu ,  CHIRILA, Costel ,  ALEXANDER, Danny ,  MILBURN, Michael ,  MITCHELL, Matthew, W. ,  GALL, Walter ,  LAWTON, Kay, A.

IPC分类号： C12Q1/00

CPC分类号： G01N33/5038 ,  G01N2800/042 ,  G01N2800/50 ,  G01N2800/56

摘要： Biomarkers relating to glucose disposal rate, insulin resistance, and/or insulin resistance-related disorders are provided. Methods based on the same biomarkers are also provided.