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1.发明公开SUBSTITUTED 1,3-CYCLOPENTADIONE ATTENUATED ENDOTHELIAL INFLAMMATION AND ENDOTHELIAL-MONOCYTE INTERACTIONS 审中-公开替代性1,3-环内酯 - 内酯 - 内含子 - 单烯突触体
公开(公告)号：EP2268600A1
公开(公告)日：2011-01-05
申请号：EP09728126.5
申请日：2009-04-02
申请人： Metaproteomics, LLC
发明人： LAMB, Joseph , KONDA, Veera , DESAI, Anu , TRIPP, Matthew, L. , DARLAND, Gary , BLAND, Jeffrey, S. , EMMA, Dennis, A.
IPC分类号： C07C49/00
CPC分类号： C07C49/707 , C07B2200/07 , C07C2601/10
摘要： Compositions and methods for reducing cardiovascular risk utilizing substituted 1,3- cyclopentadione compounds are described.
摘要翻译： 描述了使用取代的1,3-环戊二酮化合物降低心血管风险的组合物和方法。
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公开(公告)号：EP2136827A1
公开(公告)日：2009-12-30
申请号：EP08732208.7
申请日：2008-03-14
申请人： Metaproteomics, LLC
发明人： TRIPP, Mathew, L. , KONDA, Veera , DESAI, Anu , HALL, Amy, J. , BLAND, Jeffrey
摘要： Methods and compositions that can be used to promote bone and joint health through amelioration, stabilization and repair of damage associated with various pathophysiological conditions are disclosed.
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公开(公告)号：EP1993528A2
公开(公告)日：2008-11-26
申请号：EP07717798.8
申请日：2007-01-04
申请人： Metaproteomics, LLC
发明人： TRIPP, Matthew, L. , BLAND, Jeffrey, S. , LERMAN, Robert , HALL, Amy , KONDA, Veera , DESAI, Anu
CPC分类号： A61K36/185 , A61K31/12 , A61K36/53 , A61K45/06 , A61K2300/00
摘要： Compositions of reduced isoalpha acids, vitamins and minerals are disclosed as well as methods of using the same for the treatment of autoimmune diseases. Additional combinations including other compounds are also contemplated. Synergistic properties and methods exploiting such synergy are also disclosed.
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公开(公告)号：EP1976552A2
公开(公告)日：2008-10-08
申请号：EP06839296.8
申请日：2006-12-11
申请人： Metaproteomics, LLC
发明人： TRIPP, Matthew, L. , BABISH, John, G. , BLAND, Jeffrey , HALL, Amy, Jennae , KONDA, Veera , PACIORETTY, Linda , DESAI, Anu
CPC分类号： A61K36/185 , A61K31/12 , A61K36/48
摘要： Botanical compounds to modulate kinase activity are disclosed. The compounds and methods disclosed also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively. The compositions contain at least one fraction isolated or derived from hops or Acacia.
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公开(公告)号：EP2152684A1
公开(公告)日：2010-02-17
申请号：EP08729724.8
申请日：2008-02-13
申请人： Metaproteomics, LLC
发明人： TRIPP, Matthew, L. , KONDA, Veera , HALL, Amy , DESAI, Anu , BLAND, Jeffrey, S.
IPC分类号： C07D309/06
CPC分类号： C07D309/24 , A61K31/00 , A61K31/121 , A61K31/122 , A61K31/365 , A61K33/30 , C07C49/255 , C07C49/707 , C07C49/743 , A61K2300/00
摘要： Compositions and methods for enhancing heavy metal detoxification are described. The compositions and methods described provide enhanced activity of key detoxification systems including that the induction of phase II detoxification enzymes, such as glutathione s-transferases (GSTs), and NADPH quinone reductase (NQOl) activity.
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6.发明公开
公开(公告)号：EP2046353A2
公开(公告)日：2009-04-15
申请号：EP07809709.4
申请日：2007-06-20
申请人： Metaproteomics, LLC
发明人： TRIPP, Matthew, L. , BABISH, John, G. , BLAND, Jeffrey , HALL, Amy, Jennae , KONDA, Veera , PACIORETTY, Linda , DESAI, Anu
CPC分类号： A61K36/185
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on tetrahydro-isoalpha acids, commonly found in hops.
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7.发明公开
公开(公告)号：EP2046355A2
公开(公告)日：2009-04-15
申请号：EP07809708.6
申请日：2007-06-20
申请人： Metaproteomics, LLC
发明人： TRIPP, Matthew, L. , BABISH, John, G. , BLAND, Jeffrey , HALL, Amy, Jennae , KONDA, Veera , PACIORETTY, Linda , DESAI, Anu
CPC分类号： A61K36/185
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on reduced isoalpha acids, commonly found in hops.
摘要翻译： 公开了用于癌症治疗的蛋白激酶调节的化合物和方法。 所公开的化合物和方法基于通常在啤酒花中发现的还原异α酸。
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8.发明公开HEXAHYDRO-ISOALPHA ACID BASED PROTEIN KINASE MODULATION CANCER TREATMENT 审中-公开HEXAHYDRO-ISOALPHA ACID基于蛋白激酶调节癌症治疗
公开(公告)号：EP2043621A2
公开(公告)日：2009-04-08
申请号：EP07796314.8
申请日：2007-06-20
申请人： Metaproteomics, LLC
发明人： TRIPP, Matthew, L. , BABISH, John, G. , BLAND, Jeffrey , HALL, Amy, Jennae , KONDA, Veera , PACIORETTY, Linda , DESAI, Anu
IPC分类号： A61K31/122
CPC分类号： A61K36/185
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on hexahydro-isoalpha acids, commonly found in hops.
摘要翻译： 公开了用于癌症治疗的蛋白激酶调节的化合物和方法。 所公开的化合物和方法基于通常在啤酒花中发现的六氢异α酸。
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9.发明公开SUBSTITUTED 1,3-CYCLOPENTADIONE MULTI-TARGET PROTEIN KINASE MODULATORS OF CANCER, ANGIOGENESIS AND THE INFLAMMATORY PATHWAYS ASSOCIATED THEREWITH 审中-公开FOR相关的炎症，肿瘤，血管生成和量级的取代的1,3-环戊二酮-MULTI-靶蛋白激酶调节剂
公开(公告)号：EP2229178A1
公开(公告)日：2010-09-22
申请号：EP08859091.4
申请日：2008-12-10
申请人： Metaproteomics, LLC
发明人： TRIPP, Matthew, L. , BABISH, John, G. , BLAND, Jeffrey, S. , KONDA, Veera , DESAI, Anu , DARLAND, Gary , CARROLL, Brian , TRAUB, James , PACIORETTY, Linda, M , EMMA, Dennis
IPC分类号： A61K38/00
CPC分类号： A61K31/12 , A61K45/06 , A61K2300/00
摘要： Compounds and methods for multi-targeted protein kinase modulation for angiogenesis, cancer treatment or the inflammatory pathways associated with those conditions are disclosed. The compounds and methods disclosed are based on substituted 1,3-cyclopentadione compounds.
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公开(公告)号：EP2043622A2
公开(公告)日：2009-04-08
申请号：EP07845228.1
申请日：2007-06-20
申请人： Metaproteomics, LLC
发明人： TRIPP, Matthew, L. , BABISH, John, G. , BLAND, Jeffrey , HALL, Amy, Jennae , KONDA, Veera , PACIORETTY, Linda , DESAI, Anu
IPC分类号： A61K31/122
CPC分类号： A61K36/185
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on beta acids, commonly found in hops.
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