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    Composition comprising a reduced isoalpha acid, a mineral and a vitamin for use in the treatment of autoimmune diseases
    1.
    发明公开
    Composition comprising a reduced isoalpha acid, a mineral and a vitamin for use in the treatment of autoimmune diseases 审中-公开
    含有还原异α酸，矿物质和维生素，用于自身免疫疾病的治疗用组合物

    公开(公告)号：EP2604262A1

    公开(公告)日：2013-06-19

    申请号：EP13001340.2

    申请日：2007-01-04

    申请人： Metaproteomics, LLC

    发明人： Tripp, Matthew L. ,  Bland, Jeffrey S. ,  Lerman, Robert ,  Hall, Amy ,  Konda, Veera ,  Desai, Anu

    IPC分类号： A61K31/19 ,  A61K31/12 ,  A61K45/06 ,  A61P37/00

    CPC分类号： A61K36/185 ,  A61K31/12 ,  A61K36/53 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to the use of a composition comprising a synergistic combination of (a) at least one reduced isoalpha acid compound selected from the group consisting of dihydro-isohumulone, dihydro-isocohumulone, dihydro-isoadhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-isoadhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-isoadhumulone, (b) at least one mineral, and (c) at least one vitamin for the manufacture of a medicament for the treatment of an autoimmune disease in a mammal; wherein the combination of (a), (b) and (c) provides a combination index (CI) of less than 1 for synergistic inhibition of PGE2 production.

    摘要翻译： 本发明涉及包含的协同组合中使用的组合物（a）的至少一种还原异α选自二氢异葎草酮，二氢isocohumulone，二氢isoadhumulone，四氢异葎草酮，四氢 - isocohumulone的选择的酸化合物 ，四氢isoadhumulone，六氢异葎草酮，六氢isocohumulone，和六氢isoadhumulone，（b）至少一种矿物，和（c）至少一种维生素用于制造药物的用途在治疗哺乳动物自身免疫疾病的 ; worin的（a），（b）和（c）中的组合提供了小于1为PGE 2产生的协同抑制的组合指数（CI）。