公开(公告)号：EP1957498A2

公开(公告)日：2008-08-20

申请号：EP06851548.5

申请日：2006-05-19

申请人： MethylGene Inc.

发明人： SAAVEDRA, Oscar, Mario ,  CLARIDGE, Stephen, William ,  ZHAN, Lijie ,  RAEPPEL, Franck ,  VAISBURG, Arkadii ,  RAEPPEL, Stephane ,  DEZIEL, Robert ,  MANNION, Michael ,  ZHOU, Nancy ,  GAUDETTE, Frederic ,  ISAKOVIC, Ljubomir ,  WAHHAB, Amal ,  GRANGER, Marie-Claude ,  BERNSTEIN, Naomy

IPC分类号： C07D495/04

CPC分类号： C07D495/04

摘要： The invention relates to compounds of formula A, and their use for inhibiting the VEGF receptor KDR and the HGF receptor c-met Pn preferred structures of formula A, A
1 is S, A
2 =A
3 =CH, Z is O, S, S(O)
0-2 or NR
5 , Ar is phenyl, and G includes a nitrogen linker to Ar The groups D, G, and R
5 are as defined herein The invention also provides compositions and methods for treating cell proliferative diseases and conditions Examples of the diseases include breast cancer, lung cancer, colon cancer, rectal cancer, bladder cancer, leukemia and renal

摘要翻译： 本发明涉及式A化合物及其用于抑制式A的VEGF受体KDR和HGF受体c-met P n优选结构的用途，A 1是S，A 2 = A 3 = CH，Z是O，S ，S（O）0-2或NR 5，Ar为苯基，并且G包括与Ar连接的氮连接基团D，G和R 5如本文所定义。本发明还提供了用于治疗细胞增殖性疾病的组合物和方法，和 病症的例子包括乳腺癌，肺癌，结肠癌，直肠癌，膀胱癌，白血病和肾

公开(公告)号：EP1957498B1

公开(公告)日：2017-02-15

申请号：EP06851548.5

申请日：2006-05-19

申请人： MethylGene Inc.

发明人： SAAVEDRA, Oscar, Mario ,  CLARIDGE, Stephen, William ,  ZHAN, Lijie ,  RAEPPEL, Franck ,  VAISBURG, Arkadii ,  RAEPPEL, Stéphane ,  DEZIEL, Robert ,  MANNION, Michael ,  ZHOU, Nancy ,  GAUDETTE, Frederic ,  ISAKOVIC, Ljubomir ,  WAHHAB, Amal ,  GRANGER, Marie-Claude ,  BERNSTEIN, Naomy

IPC分类号： C07D495/04 ,  A61K31/4365 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61P35/00

CPC分类号： C07D495/04