公开(公告)号：EP4227407A1

公开(公告)日：2023-08-16

申请号：EP21877683.9

申请日：2021-10-06

申请人： Mican Technologies Inc. ,  OSAKA UNIVERSITY

发明人： SHIMIZU, Jun ,  TANGA, Naomi ,  YAMADA, Misuzu ,  MIYAZAKI, Kazuo ,  SHIODA, Tatsuo ,  NAKAYAMA, Emi ,  SASAKI, Tadahiro ,  KOKETSU, Ritsuko

IPC分类号： C12N5/10 ,  C07K16/10 ,  C12N5/0784 ,  C12N5/0786 ,  C12N7/02 ,  C12N15/19 ,  C12N15/57 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q1/70 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

摘要： The present invention provides human cells that can be stably infected with coronavirus, as human cells for research on infection with coronavirus such as SARS-CoV-2, as well as, by utilizing the cells, a method for confirming the presence of a coronavirus in a sample, a method for producing a coronavirus, and a method for evaluating the presence or absence of anti-coronavirus activity of a test sample or a substance having an anti-coronavirus neutralizing action in a test sample. Specifically, the present invention relates to a method for preparing a coronavirus-infectious immortalized human myeloid cell, including introducing ACE2 and TMPRSS2 into an immortalized human myeloid cell, and the like.