公开(公告)号：EP3237016A1

公开(公告)日：2017-11-01

申请号：EP15820158.2

申请日：2015-12-22

申请人： Midatech Ltd

发明人： GOLDING, Jon ,  WILLIAMS, Phillip ,  ROSKAMP, Meike

IPC分类号： A61K47/50 ,  A61P35/00

CPC分类号： A61K33/24 ,  A61K9/0014 ,  A61K47/549 ,  A61K47/6923 ,  A61K47/6929 ,  A61N5/10 ,  A61N2005/1098

摘要： The present invention provides a nanoparticle comprising a core comprising a metal; and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group, for use in a method of treating a cancer, particularly skin cancer, in a mammalian subject. Also disclosed are methods of treatment by administering the nanoparticles alone or in combination with radiotherapy.

摘要翻译： 本发明提供了包含含有金属的核的纳米颗粒; 以及包含共价连接至所述核的多个配体的电晕，所述多个配体包括至少第一种包含乙二醇部分和胺基的配体和至少第二种包含碳水化合物基团的配体种类以供使用 在哺乳动物对象中治疗癌症，特别是皮肤癌的方法中。 还公开了通过单独施用纳米颗粒或与放疗组合施用的治疗方法。