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公开(公告)号:EP2765193B1
公开(公告)日:2017-08-09
申请号:EP12838701.6
申请日:2012-10-05
申请人: Mie University , Takara Bio Inc.
IPC分类号: C12N15/09 , C07K14/705 , C07K19/00 , C12N5/10
CPC分类号: C12N15/85 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K14/70596 , C07K16/30 , C07K2319/00 , C07K2319/03 , C07K2319/30
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公开(公告)号:EP2765193A1
公开(公告)日:2014-08-13
申请号:EP12838701.6
申请日:2012-10-05
申请人: Mie University , Takara Bio, Inc.
IPC分类号: C12N15/09 , C07K14/705 , C07K19/00 , C12N5/10
CPC分类号: C12N15/85 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K14/70596 , C07K16/30 , C07K2319/00 , C07K2319/03 , C07K2319/30
摘要: Provided are a chimeric antigen receptor comprising an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, the chimeric antigen receptor being characterized in that an intracellular domain of a glucocorticoid-induced tumor necrosis factor receptor (GITR) is contained as the intracellular domain; a nucleic acid encoding the chimeric antigen receptor; a cell expressing the chimeric antigen receptor; and a method for producing the cell.
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