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公开(公告)号：EP2814791A1
公开(公告)日：2014-12-24
申请号：EP13748707.0
申请日：2013-02-14
发明人： AFROZE, Roushan , BHARATHAN, Indu, T. , CIAVARRI, Jeffrey, P. , FLEMING, Paul, E. , GAULIN, Jeffrey, L. , GIRARD, Mario , LANGSTON, Steven, P. , SOUCY, Francois, R. , WONG, Tzu-Tshin , YE, Yingchun
IPC分类号： C07B45/04
CPC分类号： C07D487/04
摘要： Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I : or a pharmaceutically acceptable salt thereof, wherein Y is and W, Z, X Y , R Y1 , R Y2 and R Y3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.
摘要翻译： 公开了抑制遍在蛋白活化酶（UAE）的化学实体，其各自为式（I）的化合物或其药学上可接受的盐，其中Y为式（II）且W，Z，XY，R Y1， 本文定义R Y2和R Y3; 包含化学实体的药物组合物; 和使用这些化学实体的方法。 这些化学实体可用于治疗疾病，特别是细胞增殖性疾病，包括癌症。
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公开(公告)号：EP3173413B1
公开(公告)日：2019-05-01
申请号：EP16205139.5
申请日：2013-02-14
发明人： AFROZE, Roushan , BHARATHAN, Indu, T. , CIAVARRI, Jeffrey, P. , FLEMING, Paul, E. , GAULIN, Jeffrey, L. , GIRARD, Mario , LANGSTON, Steven, P. , SOUCY, Francois, R. , WONG, Tzu-Tshin , YE, Yingchun
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
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公开(公告)号：EP3536692A1
公开(公告)日：2019-09-11
申请号：EP19170607.6
申请日：2013-02-14
发明人： AFROZE, Roushan , BHARATHAN, Indu, T. , CIAVARRI, Jeffrey, P. , FLEMING, Paul, E. , GAULIN, Jeffrey, L. , GIRARD, Mario , LANGSTON, Steven, P. , SOUCY, Francois, R. , WONG, Tzu-Tshin , YE, Yingchun
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
摘要： Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I :
or a pharmaceutically acceptable salt thereof, wherein Y is
and W, Z, X Y , R Y1 , R Y2 and R Y3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.-
4.发明公开5, 7-DIHYDRO- 6H-PYRIMIDO Ý 5, 4-D¨Ý 1¨BENZAZEPIN-6-THIONES AS PLK INHIBITORS 有权5,7-二氢-6H-嘧啶并[5,4-D] [1]苯并氮杂_-6-硫酮AS PLK抑制剂
公开(公告)号：EP2373657A1
公开(公告)日：2011-10-12
申请号：EP09795577.7
申请日：2009-12-04
发明人： BHARATHAN, Indu, T. , DUFFEY, Matthew, O. , ELDER, Amy, M. , GUO, Jianping , LI, Gang , REYNOLDS, Dominic , SOUCY, Francois , VOS, Tricia, J.
IPC分类号： C07D487/04 , A61K31/55 , A61P35/00
CPC分类号： C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要： This invention provides compounds of formula I: wherein R
1 , R
2 , R
3 , R
4 , R
5 , and R
6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.-
5.发明公开PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME 审中-公开吡唑并吡啶并咪唑啉酮类化合物（UBIQUITINAKTIVIERENDEN ENZYMS）
公开(公告)号：EP3173413A1
公开(公告)日：2017-05-31
申请号：EP16205139.5
申请日：2013-02-14
发明人： AFROZE, Roushan , BHARATHAN, Indu, T. , CIAVARRI, Jeffrey, P. , FLEMING, Paul, E. , GAULIN, Jeffrey, L. , GIRARD, Mario , LANGSTON, Steven, P. , SOUCY, Francois, R. , WONG, Tzu-Tshin , YE, Yingchun
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I :
or a pharmaceutically acceptable salt thereof, wherein Y is
and W, Z, X Y , R Y1 , R Y2 and R Y3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.摘要翻译： 公开了抑制泛素活化酶（UAE）的化学物质，其各自为式I化合物或其药学上可接受的盐，其中Y为和W，Z，XY，R Y1，R Y2和R Y3为 本文定义; 包含化学实体的药物组合物; 以及使用化学实体的方法。 这些化学实体可用于治疗疾病，特别是细胞增殖障碍，包括癌症。
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6.发明授权5,7-DIHYDRO-6H-PYRIMIDO[5,4-D][1]BENZAZEPIN-6-THIONES AS PLK INHIBITORS 有权5,7-二氢-6H-吡啶并[5,4-D] [1]苯并嗪-6-THIONE ALS PLK INHIBITOREN
公开(公告)号：EP2373657B1
公开(公告)日：2016-09-14
申请号：EP09795577.7
申请日：2009-12-04
发明人： BHARATHAN, Indu, T. , DUFFEY, Matthew, O. , ELDER, Amy, M. , GUO, Jianping , LI, Gang , REYNOLDS, Dominic , SOUCY, Francois , VOS, Tricia, J.
IPC分类号： A61N5/10 , C07D213/75 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04 , A61K31/55
CPC分类号： C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
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