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公开(公告)号：EP1049700B1
公开(公告)日：2005-11-09
申请号：EP99903255.0
申请日：1999-01-21
IPC分类号： C07D491/044 , A61K31/445 , A61K31/55 , A61K31/495 , C07D471/04 , C07D495/04 , C07D519/00 , C07D313/12 , C07D401/06 , C07D409/06 , C07D405/06 , C07D211/46
CPC分类号： C07D401/06 , C07D211/46 , C07D211/52 , C07D313/12 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by structural formula (I) and physiologically acceptable salts thereof.
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公开(公告)号：EP1049700A1
公开(公告)日：2000-11-08
申请号：EP99903255.0
申请日：1999-01-21
IPC分类号： C07D491/044 , A61K31/445 , A61K31/55 , A61K31/495 , C07D471/04 , C07D495/04 , C07D519/00 , C07D313/12 , C07D401/06 , C07D409/06 , C07D405/06 , C07D211/46
CPC分类号： C07D401/06 , C07D211/46 , C07D211/52 , C07D313/12 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by structural formula (I) and physiologically acceptable salts thereof.
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公开(公告)号：EP0943613A1
公开(公告)日：1999-09-22
申请号：EP97912512.7
申请日：1997-11-19
发明人： NAKASATO, Yoshisuke , OHSHIMA, Etsuo , KOIKE, Rie , ICHIMURA, Michio , MANABE, Haruhiko , SATO, Soichiro , ISHII, Hidee , YANAGAWA, Koji
IPC分类号： C07D319/18 , C07D405/06 , C07D405/12 , A61K31/335
CPC分类号： C07D405/06 , C07D319/18 , C07D405/12
摘要： Oxygen-containing heterocyclic compounds represented by following Formula (I):
wherein n represents an integer of 1 to 4; R 1 , R 2 , R 3 and R 4 are the same or different and represent hydrogen, substituted or unsubstituted lower alkyl, or the like;
R 5 represents hydrogen or halogen; R 6 represents hydroxy or substituted or unsubstituted lower alkoxy; D represents (1) -C(R 8 )(R 9 )-X- or (2) a bond; R 7 represents (1) substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, polycycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted heterocyclic group, or pyridine- N -oxide, (2) -Y-ZR 14 , (3) -Y-Z-(CH 2 ) m -N(R 16a )R 16b , or (4) -Y-CON(R 17a )R 17b , or pharmaceutically acceptable salts thereof.摘要翻译： 由下式（I）表示的含氧杂环化合物：
其中n表示1〜4的整数; R 1，R 2，R 3和R 4相同或不同，表示氢，取代或未取代的低级烷基等; R 5表示氢或卤素; R 6表示羟基或取代或未取代的低级烷氧基; D表示（1）-C（R 8）（R 9）-X-或（2）键; R 7表示（1）取代或未取代的低级烷基，取代或未取代的环烷基，多环烷基，取代或未取代的芳基，取代或未取代的芳烷基，取代或未取代的芳族杂环基，取代或未取代的杂环基或吡啶-N （2）-Y-ZR 14，（3）-YZ-（CH2）mN（R 16a）R 16b或（4）-Y-CON（R 17a）R <17b>或其药学上可接受的盐。 -
公开(公告)号：EP1448566B3
公开(公告)日：2009-04-08
申请号：EP02789725.5
申请日：2002-11-13
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G. , GHOSH, Shomir , ELDER, Amy, M. , MATTIA, Karen, M.
IPC分类号： C07D491/04 , C07D471/04 , C07D519/00 , C07D513/04 , A61K31/4353 , A61K31/55 , A61P29/00 , A61P1/00 , A61P3/10 , C07D313/00 , C07D221/00 , C07D223/00
CPC分类号： C07D491/04 , C07D211/46
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.
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公开(公告)号：EP1204664A1
公开(公告)日：2002-05-15
申请号：EP00952317.6
申请日：2000-07-28
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , SONE, Hiroki , KOTERA, Osamu , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G.
IPC分类号： C07D491/04 , C07D495/04 , C07D401/06 , C07D451/06 , C07D519/00 , C07D471/04 , A61K31/4353 , A61K31/436 , A61K31/4365 , A61K31/55 , A61P37/00
CPC分类号： C07D401/06 , C07D471/04 , C07D491/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by (1) or Z-Y-(CH2)n -X-NR50R5 and physiologically acceptable salts thereof.
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公开(公告)号：EP1204665B1
公开(公告)日：2009-01-07
申请号：EP00950880.5
申请日：2000-07-28
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , SONE, Hiroki , KOTERA, Osamu , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G.
IPC分类号： C07D491/044 , A61K31/4353 , A61K31/4365 , A61K31/55 , A61K31/451 , A61P29/00 , C07D409/06 , C07D401/06 , C07D211/52 , C07D405/06 , C07D471/04 , C07D519/00 , C07D495/04
CPC分类号： C07D401/06 , C07D211/46 , C07D211/52 , C07D313/12 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by (I) or (II) and physiologically acceptable salts thereof.
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公开(公告)号：EP1049700B9
公开(公告)日：2006-05-10
申请号：EP99903255.0
申请日：1999-01-21
IPC分类号： C07D491/044 , A61K31/445 , A61K31/55 , A61K31/495 , C07D471/04 , C07D495/04 , C07D519/00 , C07D313/12 , C07D401/06 , C07D409/06 , C07D405/06 , C07D211/46 , C07D313/00 , C07D221/00
CPC分类号： C07D401/06 , C07D211/46 , C07D211/52 , C07D313/12 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by structural formula (I) and physiologically acceptable salts thereof.
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公开(公告)号：EP1448566B1
公开(公告)日：2006-03-15
申请号：EP02789725.5
申请日：2002-11-13
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G. , GHOSH, Shomir , ELDER, Amy, M. , MATTIA, Karen, M.
IPC分类号： C07D491/04 , C07D471/04 , C07D519/00 , C07D513/04 , A61K31/4353 , A61K31/55 , A61P29/00 , A61P1/00 , A61P3/10 , C07D313/00 , C07D221/00 , C07D223/00
CPC分类号： C07D491/04 , C07D211/46
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.
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公开(公告)号：EP1204665A2
公开(公告)日：2002-05-15
申请号：EP00950880.5
申请日：2000-07-28
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , SONE, Hiroki , KOTERA, Osamu , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G.
IPC分类号： C07D491/044 , A61K31/4353 , A61K31/4365 , A61K31/55 , A61K31/451 , A61P29/00 , C07D409/06 , C07D401/06 , C07D211/52 , C07D405/06 , C07D471/04 , C07D519/00 , C07D495/04
CPC分类号： C07D401/06 , C07D211/46 , C07D211/52 , C07D313/12 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by (I) or (II) and physiologically acceptable salts thereof.
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公开(公告)号：EP1448566A2
公开(公告)日：2004-08-25
申请号：EP02789725.5
申请日：2002-11-13
发明人： LULY, Jay, R. , NAKASATO, Yoshisuke , OHSHIMA, Etsuo , HARRIMAN, Geraldine, C., B. , CARSON, Kenneth, G. , GHOSH, Shomir , ELDER, Amy, M. , MATTIA, Karen, M.
IPC分类号： C07D491/04 , C07D471/04 , C07D519/00 , C07D513/04 , A61K31/4353 , A61K31/55 , A61P29/00 , A61P1/00 , A61P3/10
CPC分类号： C07D491/04 , C07D211/46
摘要： Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.
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