公开(公告)号：EP1907387A1

公开(公告)日：2008-04-09

申请号：EP06781142.2

申请日：2006-07-10

申请人： Mitsubishi Tanabe Pharma Corporation

发明人： SUGAWARA, Kazutoshi ,  MATSUDAIRA, Tetsuji ,  SUGAMA, Hiroshi ,  NAWANO, Masao ,  OHASHI, Rikiya

IPC分类号： C07D417/12 ,  C07D417/14 ,  C07D513/04 ,  C07D213/75 ,  C07D277/46 ,  C07D285/08 ,  C07D241/20 ,  C07D403/06 ,  C07D405/12 ,  C07D405/14 ,  A61K31/433 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  C07C251/32

CPC分类号： C07D405/12 ,  A61K31/433 ,  C07D213/75 ,  C07D241/20 ,  C07D277/46 ,  C07D285/01 ,  C07D403/06 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

摘要： The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: wherein Ring A is aryl or heteroaryl; Q is cycloalkyl, heterocycle, alkyl or alkenyl; Ring T is heteroaryl or heterocycle; R1 and R2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl or the like; R3 and R4 are independently hydrogen atom, hydroxy, oxo, halogen atom or the like; R5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl or the like; or a pharmaceutically acceptable salt thereof.