公开(公告)号：EP0996453A1

公开(公告)日：2000-05-03

申请号：EP98924521.2

申请日：1998-06-23

申请人： Mohler, Hanns ,  Boison, Detlev

发明人： Mohler, Hanns ,  Boison, Detlev

IPC分类号： A61K31/70 ,  C12N5/06

CPC分类号： A61K31/7076 ,  A61K9/0085 ,  A61K31/704 ,  A61K38/00 ,  C12N15/1137 ,  C12N2310/111

摘要： The present invention relates to the treatment of conditions associated with neuronal activity. Specifically, the invention is drawn to methods and compositions for administering adenosine to inhibit pain syndromes or epilepsy in a patient.

公开(公告)号：EP0996453B1

公开(公告)日：2004-04-28

申请号：EP98924521.2

申请日：1998-06-23

申请人： Mohler, Hanns ,  Boison, Detlev

发明人： Mohler, Hanns ,  Boison, Detlev

IPC分类号： A61K31/70 ,  C12N5/06 ,  A61P25/00

CPC分类号： A61K31/7076 ,  A61K9/0085 ,  A61K31/704 ,  A61K38/00 ,  C12N15/1137 ,  C12N2310/111

公开(公告)号：EP1337859A1

公开(公告)日：2003-08-27

申请号：EP01972393.1

申请日：2001-10-05

申请人： Mohler, Hanns ,  Rudolph, Uwe

发明人： Mohler, Hanns ,  Rudolph, Uwe

IPC分类号： G01N33/94 ,  A61K31/00

CPC分类号： G01N33/94 ,  A61K31/00 ,  A61K31/5513

摘要： The present invention relates to selective anxiolytic therapeutic agents which allow for the treatment of anxiety-related disorders with less severe side-effects, such as sedative and amnesic effects, and in particular, dependence liability. These selective agents selectively or preferentially bind the α2-GABAA receptor, as compared to the α1-GABAA receptor. Alternatively, these selective agents selectively or preferentially activate the α2-GABAA receptor, as compared to the α1-GABAA receptor. The present invention also relates to methods for identifying such selective anxiolytic therapeutic agents. The present invention also relates to methods for identifying a molecule that decreases binding of a benzodiazepine to the α1-GABAA receptor, but not substantially to the α2-GABAA receptor.