公开(公告)号：EP1363658A2

公开(公告)日：2003-11-26

申请号：EP02714031.8

申请日：2002-02-19

申请人： Mologen Forschungs-, Entwicklungs- und Vertriebs GmbH

发明人： WITTIG, Burghardt ,  STEIN, Christoph ,  SCHÄFER, Michael ,  SCHROFF, Matthias ,  JUNGHANS, Claas ,  KÖNIG MEREDIZ, Sven Andres

IPC分类号： A61K38/33

CPC分类号： A61K38/33 ,  A61K38/35 ,  A61K48/00 ,  A61K48/0075 ,  A61K2039/53 ,  C07K14/57509 ,  C07K14/665 ,  C07K14/675 ,  C07K14/69 ,  C07K14/695 ,  C07K2319/00

摘要： The invention relates to an agent for calming the sensation of pain, in particular in chronic inflammatory disorders, by the expression of endogenic, neuroendocrine peptides at the inflammation site. The invention relates in particular to the expression of POMC or CRF from locally injected DNA expression constructs, preferably covalently peptide-modified expression constructs.

公开(公告)号：EP1196178A1

公开(公告)日：2002-04-17

申请号：EP00912392.8

申请日：2000-02-24

申请人： Mologen Forschungs-, Entwicklungs- und Vertriebs GmbH

发明人： JUNGHANS, Claas ,  WITTIG, Burghardt ,  KÖNIG MEREDIZ, Sven ,  SCHROFF, Matthias

IPC分类号： A61K31/713 ,  A61K31/711 ,  A61P37/04

CPC分类号： C12N15/117 ,  A61K2039/55561 ,  C12N2310/18 ,  C12N2310/53

摘要： The invention relates to deoxyribonucleic acid molecules that are useful for stimulating the immune response in higher animals or humans, especially those deoxyribonucleic acid molecules that comprise unmethylated CpG-containing sequences with immunostimulatory properties. According to the invention, said molecules are composed of a partially self-complementary, covalently closed circular single strand that is structured as a loop. The inventive molecules have a higher stability in vivo or a higher compatibility vis-à-vis immunostimulatory nucleic acid sequences.