公开(公告)号：EP2315660A1

公开(公告)日：2011-05-04

申请号：EP09808712.5

申请日：2009-08-18

申请人： MonoSol RX LLC

发明人： MYERS, Garry ,  HARIHARAN, Madhusudan ,  SANGHVI, Pradeep ,  SZOPINSKI, Alex ,  DAILEY, Patrick

IPC分类号： B32B1/00

CPC分类号： A61K9/7007 ,  A23P30/00 ,  A61K31/485

摘要： The present invention relates to a method of making a film composition with an improved uniformity of active composition The invention includes a method including the steps of forming a flowable film composition comprising an edible water-soluble polymer, a polar solvent and a particulate active suspended therein, where the ratio of solids to liquids is at least about 95 to about 5 and where the composition compπses a mixture having compositional uniformity per unit volume, directing the flowable film composition to a transfer trough, the transfer trough including a first rotating roller and a movable transfer substrate upon which to form the film, and maintaining uniformity of the flowable film composition dunng the residence time in the trough by maintaining the rate of composition enteπng the transfer trough and the level of the flowable film composition in the transfer trough at a substantially constant level