公开(公告)号：EP1819736A2

公开(公告)日：2007-08-22

申请号：EP05847825.6

申请日：2005-12-02

申请人： Morphotek, Inc.

发明人： GRASSO, Luigi ,  DESHMUKH, Gaurav ,  NICOLAIDES, Nicholas ,  SASS, Philip

IPC分类号： C07K16/28 ,  C12N5/10 ,  G01N33/50 ,  C12N15/13

CPC分类号： G01N33/574 ,  C07K16/2851 ,  G01N33/56966 ,  G01N33/57492 ,  G01N2333/515 ,  G01N2333/70596 ,  G01N2500/00 ,  G01N2800/10 ,  G01N2800/16 ,  G01N2800/24

摘要： Monoclonal antibodies and other proteins that specifically bind to cells positive for endosialin are provided. The antibodies and proteins are useful in the isolation of endosialin-positive cells, particularly cells associated with neovascularization associated with cancer and neovascular disease. The invention is also related to cells that are isolated using monoclonal antibodies; antibody derivatives, such as chimeric and humanized monoclonal antibodies; antibody fragments; mammalian cells expressing the monoclonal antibodies, derivatives and fragment; and methods of detecting and isolation endosialin-positive cells using the antibodies, derivatives and fragments.

公开(公告)号：EP1819736B1

公开(公告)日：2010-08-04

申请号：EP05847825.6

申请日：2005-12-02

申请人： Morphotek, Inc.

发明人： GRASSO, Luigi ,  DESHMUKH, Gaurav ,  NICOLAIDES, Nicholas ,  SASS, Philip

IPC分类号： C07K16/28 ,  C12N5/10 ,  G01N33/50 ,  C12N15/13

CPC分类号： G01N33/574 ,  C07K16/2851 ,  G01N33/56966 ,  G01N33/57492 ,  G01N2333/515 ,  G01N2333/70596 ,  G01N2500/00 ,  G01N2800/10 ,  G01N2800/16 ,  G01N2800/24

摘要： Monoclonal antibodies and other proteins that specifically bind to cells positive for endosialin are provided. The antibodies and proteins are useful in the isolation of endosialin-positive cells, particularly cells associated with neovascularization associated with cancer and neovascular disease. The invention is also related to cells that are isolated using monoclonal antibodies; antibody derivatives, such as chimeric and humanized monoclonal antibodies; antibody fragments; mammalian cells expressing the monoclonal antibodies, derivatives and fragment; and methods of detecting and isolation endosialin-positive cells using the antibodies, derivatives and fragments.

摘要翻译： 提供了特异性结合内皮唾液酸蛋白阳性细胞的单克隆抗体和其他蛋白质。 抗体和蛋白质可用于分离内皮唾液酸蛋白阳性细胞，特别是与癌症和新血管疾病相关的新血管生成有关的细胞。 本发明还涉及使用单克隆抗体分离的细胞; 抗体衍生物，如嵌合和人源化单克隆抗体; 抗体片段; 表达单克隆抗体，衍生物和片段的哺乳动物细胞; 以及使用抗体，衍生物和片段检测和分离内皮唾液酸蛋白阳性细胞的方法。