公开(公告)号：EP4446404A1

公开(公告)日：2024-10-16

申请号：EP21967317.5

申请日：2021-12-08

申请人： Mthera Pharma Co., Ltd.

发明人： SOHN, Mi Won ,  CHOI, Jin Gyu ,  KIM, Sinyeon ,  PARK, Sang Cheol ,  KIM, Dong Hyun ,  KIM, Sun Yeou ,  HONG, Sung Min ,  OH, Myung Sook ,  JU, In Gyoung ,  LEE, Choong Hwan

IPC分类号： C12N1/20 ,  A61K35/742 ,  A61P25/00 ,  A61P1/14 ,  A23L33/135 ,  A23K10/16 ,  C12R1/225

摘要： The present invention relates to a novel Lactobacillus paracasei NK112 strain that has the effect of preventing or treating cognitive dysfunction and intestinal dysfunction. In addition, the present invention relates to a composition for prevention, treatment, or alleviation of cognitive dysfunction and intestinal dysfunction, comprising a Lactobacillus paracasei NK112 strain, a Cuscuta australis R.Br. extract, and a Cuscuta japonica Choisy extract. The strain and the composition, of the present invention, exhibit efficacy in increasing the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), alleviating intestinal inflammation, and the like, and thus can be effectively used in the prevention or treatment of cognitive dysfunction and intestinal dysfunction.