公开(公告)号：EP1680444A1

公开(公告)日：2006-07-19

申请号：EP04744087.0

申请日：2004-07-29

申请人： Mymetics Corporation

发明人： FLEURY, Sylvain ,  GIRARD, Marc ,  ROGER, Marie-Gaëlle ,  MOUZ, Nicolas ,  SERRES, Pierre-François

IPC分类号： C07K14/16 ,  C12N15/48 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/57 ,  C07K2319/00 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention concerns a modified polypeptide containing at least an immunodominant region and the connecting loop between N- and C-helices of gp41 ectodomain of HIV-1, wherein the connecting loop includes at least a linker fragment having: - a size convenient for keeping the native conformation of the interaction between N- and C-helices, and - an hydrophily sufficient to provide a soluble and stable trimeric form to said modified polypeptide.