公开(公告)号：EP2197445A2

公开(公告)日：2010-06-23

申请号：EP08787554.8

申请日：2008-08-28

申请人： N.V. Organon

发明人： KARSTENS, Willem, Frederik, Johan ,  CONTI, Paolo, Giovanni, Martino ,  TIMMERS, Cornelis, Marius ,  PLATE, Ralf ,  VAN KOPPEN, Christianus, Johannes

IPC分类号： A61K31/47 ,  A61P5/08 ,  C07D215/38

CPC分类号： C07D215/38 ,  A61K31/47 ,  A61K31/4709 ,  C07D401/10 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

摘要： The present invention relates the use of a compound, a pharmaceutical composition, compounds and a kit for treating or preventing disorders in a mammal responsive to TSH receptor mediated pathways, including disorders such as hyperthyroidism, Graves' disease, Graves Ophthalmopathy, Graves' associated pretibial dermopathy, nodular goitre and thyroid cancer comprising administering to said mammal an effective amount of a tetrahydroquinoline compound of Formula (I) or an pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及化合物，药物组合物，化合物和用于治疗或预防针对TSH受体介导的途径的哺乳动物疾病的试剂盒的应用，包括诸如甲状腺机能亢进，格雷夫斯病，格雷夫斯眼病，格雷夫斯相关的前囟素 皮肤病，结节性甲状腺肿和甲状腺癌，包括向所述哺乳动物施用有效量的式（I）的四氢喹啉化合物或其药学上可接受的盐。