公开(公告)号：EP2954905A4

公开(公告)日：2016-11-09

申请号：EP13868860

申请日：2013-12-26

申请人： NAKAJIMA TOSHIHIRO

发明人： NAKAJIMA TOSHIHIRO ,  FUJITA HIDETOSHI ,  ARATANI SATOKO ,  YAGISHITA NAOKO

IPC分类号： A61K45/00 ,  A61P3/04 ,  A61P43/00 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50

CPC分类号： G01N33/573 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N33/6875 ,  G01N2333/70567 ,  G01N2333/9015 ,  G01N2440/36 ,  G01N2500/04 ,  G01N2500/10

摘要： [Problem] To provide a mitochondria-function regulator effective for treatment or prevention of obesity, and a screening method therefore. [Solution] The mitochondria-function regulator of the present invention contains, as an active ingredient, a PGC-1² - protein function regulator synoviolin. The screening method of the present invention includes a step for causing a test substance to act on an adipose tissue cell or an individual animal, and measuring or detecting one or more of the following in the adipose tissue cell: (1) expression level of synoviolin; (2) a bond between synoviolin and PGC-1² protein; and (3) the ubiquitination of the PGC-1² protein by synoviolin.

摘要翻译： [问题]为了提供一种线粒体功能调节剂有效地用于治疗或预防肥胖症，因此筛选方法。 [解决方案本发明的线粒体功能调节剂含有作为活性成分的，一个PGC-1² - 蛋白功能调节synoviolin。 本发明的筛选方法包括用于使被检物质在脂肪组织细胞或个体动物作用于，并测量或检测在脂肪组织细胞以下的一个或多个步骤：（1）synoviolin的表达水平 ; （2）synoviolin和PGC-1²蛋白之间的键; 和（3）蛋白PGC-1²通过synoviolin的泛素化。

公开(公告)号：EP3135292A4

公开(公告)日：2018-01-24

申请号：EP15756030

申请日：2015-02-27

申请人： NAKAJIMA TOSHIHIRO ,  FMS CO LTD

发明人： ARATANI SATOKO ,  YAGISHITA NAOKO ,  FUJITA HIDETOSHI

IPC分类号： A61K36/52 ,  A23L33/105 ,  A61P3/04 ,  A61P3/06 ,  A61P43/00

CPC分类号： A61K36/52 ,  A23L33/105 ,  A23L33/30 ,  A61K9/0053 ,  A61K2236/33 ,  A61K2236/37 ,  A61K2236/39 ,  A61K2236/51 ,  A61K2236/53

摘要： [Problem] To provide an antiobesity agent. [Solution] An antiobesity agent containing an extract of walnut branches, shells, or leaves as an active ingredient.

公开(公告)号：EP2940132A4

公开(公告)日：2016-08-17

申请号：EP13867673

申请日：2013-12-19

申请人： NAKAJIMA TOSHIHIRO

发明人： NAKAJIMA TOSHIRO ,  FUJITA HIDETOSHI ,  ARATANI SATOKO ,  YAGISHITA NAOKO

IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K31/713 ,  A61P3/04 ,  C12Q1/02 ,  G01N33/50

CPC分类号： C12N15/1137 ,  A61K31/7088 ,  A61K31/713 ,  C12N15/09 ,  C12N2310/14 ,  G01N33/5023 ,  G01N2333/9015 ,  G01N2800/044

摘要： [Problem] To provide a screening method for a substance having an anti-obesity action and an anti-obesity drug. [Solution] A screening method including: a step for contacting a test substance and a synoviolin-gene-expressing cell; and a step for verifying the effect of the test substance on the synoviolin gene expression, or the effect thereof on synoviolin protein activity. An action which reduces the amount of adipose tissue and an action which inhibits induction of adipocyte differentiation are examples of an anti-obesity action. An anti-obesity drug containing, as an active ingredient thereof, an siRNA of synoviolin, a decoy nucleic acid of synoviolin, or an antisense nucleic acid of synoviolin.