公开(公告)号：EP0713395A1

公开(公告)日：1996-05-29

申请号：EP94923410.0

申请日：1994-07-12

申请人： NEORX CORPORATION

发明人： GUSTAVSON, Linda M. ,  ANDERSON, David C. ,  MORGAN, Alton C., Jr.

IPC分类号： A61K47 ,  C07K14 ,  A61K38

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K47/62 ,  A61K47/6883 ,  A61K47/6897 ,  A61K47/6898 ,  C07K14/36 ,  C07K14/465 ,  C07K14/47 ,  C07K14/473 ,  C07K14/721 ,  C07K14/723 ,  C07K14/76

摘要： Polymeric carriers are polypeptides comprising at least one drug-binding domain that non-covalently binds a drug. A polymeric carrier may be attached to an antibody specific for desired target cells to form immunoconjugates that deliver a drug to the target cells in vivo. A polymeric carrier may be attached to a proteinaceous or a non-proteinaceous ligand or anti-ligand to form a conjugate useful in pretargeting protocols to deliver a drug to target cells in vivo. The carriers are derived from drug-binding proteins and produced through peptide synthesis or recombinant DNA technology.