公开(公告)号：EP2324008A1

公开(公告)日：2011-05-25

申请号：EP09780990.9

申请日：2009-07-23

申请人： NERVIANO MEDICAL SCIENCES S.R.L.

发明人： PULICI, Maurizio ,  ZUCCOTTO, Fabio ,  BADARI, Alessandra ,  NUVOLONI, Stefano ,  CERVI, Giovanni ,  TRAQUANDI, Gabriella ,  BIONDARO, Sonia ,  TRIFIRO', Paolo ,  MARCHIONNI, Chiara ,  MODUGNO, Michele

IPC分类号： C07D401/04 ,  C07D403/04 ,  C07D407/14 ,  C07D409/14 ,  A61K31/4439 ,  A61P35/00

CPC分类号： C07D401/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/635 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D513/14

摘要： 3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

公开(公告)号：EP2324008B1

公开(公告)日：2012-05-09

申请号：EP09780990.9

申请日：2009-07-23

申请人： NERVIANO MEDICAL SCIENCES S.R.L.

发明人： PULICI, Maurizio ,  ZUCCOTTO, Fabio ,  BADARI, Alessandra ,  NUVOLONI, Stefano ,  CERVI, Giovanni ,  TRAQUANDI, Gabriella ,  BIONDARO, Sonia ,  TRIFIRO', Paolo ,  MARCHIONNI, Chiara ,  MODUGNO, Michele

IPC分类号： C07D401/04 ,  C07D403/04 ,  C07D407/14 ,  C07D409/14 ,  A61K31/4439 ,  A61P35/00

CPC分类号： C07D401/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/635 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D513/14

摘要： 3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.