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公开(公告)号：EP3333166B1
公开(公告)日：2019-11-06
申请号：EP17195806.9
申请日：2013-05-22
IPC分类号： C07D405/12 , A61K31/496 , A61P35/00
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公开(公告)号：EP3290414B1
公开(公告)日：2019-07-24
申请号：EP17192138.0
申请日：2013-05-22
IPC分类号： C07D405/12 , A61K31/496 , A61P35/00
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3.发明授权PROCESS FOR THE PREPARATION OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE 无效制备N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2-（四氢吡喃 - -4-基氨基） - 苯甲酰胺
公开(公告)号：EP2855460B1
公开(公告)日：2017-11-08
申请号：EP13724270.7
申请日：2013-05-22
IPC分类号： C07D405/12 , A61K31/496 , A61P35/00
CPC分类号： A61K31/496 , A61P35/00 , C07B2200/13 , C07D405/12 , C07D405/14
摘要： The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention..
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公开(公告)号：EP3581571A1
公开(公告)日：2019-12-18
申请号：EP19188774.4
申请日：2013-05-22
IPC分类号： C07D405/12 , A61K31/496 , A61P35/00
摘要： The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention
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公开(公告)号：EP3333166A1
公开(公告)日：2018-06-13
申请号：EP17195806.9
申请日：2013-05-22
IPC分类号： C07D405/12 , A61K31/496 , A61P35/00
摘要： The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
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6.发明公开CRYSTALLINE FORM OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE 有权N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2-（四氢吡喃-4-基） 氨基） - 苯甲酰胺
公开(公告)号：EP3290414A1
公开(公告)日：2018-03-07
申请号：EP17192138.0
申请日：2013-05-22
IPC分类号： C07D405/12 , A61K31/496 , A61P35/00
CPC分类号： A61K31/496 , A61P35/00 , C07B2200/13 , C07D405/12 , C07D405/14
摘要： The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention..
摘要翻译： 本发明涉及制备N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2 - （四氢 - 吡喃-4-基氨基） - 苯甲酰胺。 这种化合物的新固体形式，它们在治疗由失调的蛋白激酶活性引起的疾病中的效用以及含有它们的药物组合物也是本发明的目的。
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7.发明公开PROCESS FOR THE PREPARATION OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE 无效VERFAHREN ZUR HERSTELLUNG VON N- [5-（3,5-二氟苄基）-1H-吲哚-3-基] -4-（4-甲基 - 哌嗪-1-基）-2-（四氢 - 吡喃-4-基）氨基] ）-BENZAMID
公开(公告)号：EP2855460A1
公开(公告)日：2015-04-08
申请号：EP13724270.7
申请日：2013-05-22
IPC分类号： C07D405/12 , A61K31/496 , A61P35/00
CPC分类号： A61K31/496 , A61P35/00 , C07B2200/13 , C07D405/12 , C07D405/14
摘要： The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention..
摘要翻译： 本发明涉及制备N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2 - （四氢 - 吡喃-4-基氨基） - 苯甲酰胺。 这种化合物的新型固体形式，它们在治疗由失调的蛋白激酶活性引起的疾病中的应用以及含有它们的药物组合物也是本发明的目的。
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公开(公告)号：EP2049530A2
公开(公告)日：2009-04-22
申请号：EP07786952.7
申请日：2007-06-29
发明人： FORINO, Romualdo , BARBUGIAN, Natale Alvaro , TOMASI, Attilio , VISENTIN, Giuseppina , CATTANEO, Marco , ZAMPIERI, Massimo
IPC分类号： C07D413/04 , A61K31/535 , A61P35/00
CPC分类号： C07D413/04
摘要： This invention relates to a novel crystalline polymorphic form of nemorubicin hydrochloride dihydrate, useful for the preparation of pharmaceutical composition for the treatment of tumors. A process for preparing this novel polymorphic form, named form A, is within the scope of the present invention.
摘要翻译： 本发明涉及新型结晶多晶型盐酸奈莫柔比星二水合物，可用于制备治疗肿瘤的药物组合物。 用于制备这种称为形式A的新颖多晶型物的方法在本发明的范围内。
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