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公开(公告)号：EP2707359A1
公开(公告)日：2014-03-19
申请号：EP12718275.6
申请日：2012-05-07
IPC分类号： C07D231/56 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/416 , A61P35/00
CPC分类号： A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D295/155 , C07D295/185 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C12N9/12 , C12Y207/10001
摘要： The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
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2.发明公开ANTITUMOR COMBINATION COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ANTIBODIES INHIBITING GROWTH FACTORS OR THEIR RECEPTORS 有权取代的丙烯衍生物偏端霉素和生长因子或它们的受体炎症性抗体的抗肿瘤组合
公开(公告)号：EP1868599A1
公开(公告)日：2007-12-26
申请号：EP06725409.4
申请日：2006-03-29
IPC分类号： A61K31/40 , A61K39/395 , A61P35/00
CPC分类号： A61K31/40 , A61K39/395 , A61K39/39533 , A61K39/39558 , C07K2317/24 , A61K2300/00
摘要： The present invention provides the combined use of acryloyl distamycin derivatives, in particular α-bromo- and α-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and an antibody inhibiting a growth factor or its receptor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
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公开(公告)号：EP2323664B1
公开(公告)日：2015-01-07
申请号：EP09781195.4
申请日：2009-07-28
IPC分类号： A61K31/519 , A61K31/4188 , A61K45/06 , A61P35/00
CPC分类号： A61K31/519 , A61K31/4188 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2323664A1
公开(公告)日：2011-05-25
申请号：EP09781195.4
申请日：2009-07-28
IPC分类号： A61K31/519 , A61K31/53 , A61K31/4188 , A61K45/06
CPC分类号： A61K31/519 , A61K31/4188 , A61K45/06 , A61K2300/00
摘要： The invention provides a lowmolecular weight ATP-competitive CDK inhibitor able to cross the blood brain barrier for use in the treatment of malignant glioma and, in particular, of glioblastoma. The compound can be administered together with one or more agents selected from the group consisting of cytotoxic or cytostatic agents and ionizing radiation.
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公开(公告)号：EP2707359B1
公开(公告)日：2016-11-30
申请号：EP12718275.6
申请日：2012-05-07
IPC分类号： C07D231/56 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/416 , A61P35/00
CPC分类号： A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D295/155 , C07D295/185 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C12N9/12 , C12Y207/10001
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公开(公告)号：EP2408776A1
公开(公告)日：2012-01-25
申请号：EP10708552.4
申请日：2010-03-15
发明人： SCABURRI, Angela , PACCIARINI, Maria Adele , CIOMEI, Marina , LAFFRANCHI, Bernard , COMIS, Silvia
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention provides a low molecular weight ATP-competitive CDK inhibitor and TRKA inhibitor of formula (I) for use in the treatment of thymoma and thymic carcinoma. The compound can be administered together with one or more cytotoxic or cytostatic agents.
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7.发明授权THERAPEUTIC COMBINATION COMPRISING A CDKs INHIBITOR AND AN ANTINEOPLASTIC AGENT 有权EINEM ANTINEOPLASTISCHEN MITTEL治疗麻醉师EINEM CDKS-INHIBITOR
公开(公告)号：EP2320903B1
公开(公告)日：2017-01-18
申请号：EP09781243.2
申请日：2009-07-29
IPC分类号： A61K31/519 , A61K31/513 , A61K31/7068 , A61K45/06 , A61P35/00
CPC分类号： A61K31/7068 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/519 , A61K31/555 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2408776B1
公开(公告)日：2014-01-08
申请号：EP10708552.4
申请日：2010-03-15
发明人： SCABURRI, Angela , PACCIARINI, Maria Adele , CIOMEI, Marina , LAFFRANCHI, Bernard , COMIS, Silvia
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519
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9.发明公开THERAPEUTIC COMBINATION COMPRISING A CDKS INHIBITOR AND AN ANTINEOPLASTIC AGENT 审中-公开包含CDKS抑制剂和抗移植药物的治疗组合
公开(公告)号：EP3173100A1
公开(公告)日：2017-05-31
申请号：EP17151885.5
申请日：2009-07-29
IPC分类号： A61K45/06 , A61K31/513 , A61K31/519 , A61K31/7068 , A61K31/4745 , A61K31/495 , A61K31/555 , A61P35/00
CPC分类号： A61K31/7068 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/519 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The present invention provides a therapeutic combination comprising (a) a compound of formula (I) as set forth in the specification and (b) one or more antineoplastic agents selected from the group consisting of alkylating or alkylating-like agents, antimetabolite agents and topoisomerase I inhibitors, wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof.
摘要翻译： 本发明提供了治疗组合，其包含（a）如说明书中所述的式（I）化合物和（b）一种或多种选自烷化剂或烷化剂的药物，抗代谢药和拓扑异构酶 I抑制剂，其中活性成分在每种情况下以游离形式或以药学上可接受的盐或其任何水合物的形式存在。
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公开(公告)号：EP2376084B1
公开(公告)日：2013-07-17
申请号：EP09760831.9
申请日：2009-11-23
发明人： CIOMEI, Marina , SCABURRI, Angela
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： A61K31/519
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